Results 51 to 60 of about 560,457 (289)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Вестник Научно-исследовательского института железнодорожного транспорта, 2020 Problem of ensuring stability of railway automation systems to ultra-wideband pulses of an electromagnetic field is considered. These pulses can be used to intentionally affect the equipment of these systems.
D. V. Komnatnyy
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The forming and emission of high power electromagnetic pulses
ITM Web of Conferences, 2018 An impulse energy source, a power conditioning system and an electromagnetic field emitter are essential to generate an electromagnetic field pulse (EMFP) with a specific frequency bandwidth.
Jakubiuk Kazimierz +2 more
doaj +1 more source
ON AN IMPULSE INTERVAL GENERATING MECHANISM
The Japanese Journal of Physiology, 1964 1. Some of the data obtained by HAGIWARA (1954) on the interval fluctuations of the sensory nerve impulse have been reanalysed with a modified model.2. The modification consisted essentially of the introduction of a factor characterizing the rate of fluctuation of a random process that is thought to be super-imposed on the threshold of the impulse ...
openaire +3 more sources
Impulsivity in the general population: A national study [PDF]
Journal of Psychiatric Research, 2012 The construct of impulsivity is an important determinant of personality differences, psychiatric disorders, and associated risk-taking behaviors. Most existing knowledge about impulsivity comes from clinical samples. To date, no study has estimated the prevalence of impulsivity and examined its correlates in the general population.We analyzed data from
Jaime, Chamorro +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Derivation of Load Peak Voltage, Power Consumption and Potential Energy Management in a Thyristor Controlled Marx Impulse Generator for Capacitor Discharge Application [PDF]
, 2013 Calculation of the load peak voltage, potential energy and power consumption of a Marx impulse generator, as a function of time, are presented. The equations are generalized and can be used to the design of any type of n-stage Marx impulse generator ...
Y., Ali Sai'd +8 more
core +6 more sources
An Impulse Generator Simulation Circuit [PDF]
, 2002 This thesis describes the creation of a simulation circuit to match the output of a Marx type Impulse Generator. The goal was to estimate the stray capacitance and insert that capacitance into the simulation circuit to effectively produce an output ...
Meiners, Steven Edward
core
TRANSMISSION AND RECEPTION OF UWB SIGNALS BASED ON ANTENNA DECODING
Information and Telecommunication Sciences, 2018 Background. A new idea for receiving and transmitting impulse radio ultrawideband signals with Pulse Position Coding (PPC) in transmitter station and antenna decoding in receiver station is proposed.
Gleb Avdeyenko +2 more
doaj +1 more source