Results 41 to 50 of about 7,055 (265)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Generalized symmetries of impulsive gravitational waves [PDF]

Classical and Quantum Gravity, 1997
We generalize previous \cite{AiBa2} work on the classification of ($C^\infty$) symmetries of plane-fronted waves with an impulsive profile. Due to the specific form of the profile it is possible to extend the group of normal-form-preserving diffeomorphisms to include non-smooth transformations.
Aichelburg, Peter C., Balasin, Herbert
openaire   +2 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

IR-UWB antenna with built-in impulse-like waveform generator for impulse radar applications

AIP Advances
This paper presents a novel impulse-radio ultra-wideband (IR-UWB) pulsed radar antenna integrated with an impulse generator circuit, designed and investigated for IR-UWB radar imaging applications.
D. Lee
doaj   +1 more source

Impulse noise generated by starter pistols [PDF]

International Journal of Audiology, 2013
This study describes signals generated by .22 and .32 caliber starter pistols in the context of noise-induced hearing loss risk for sports officials and athletes.Acoustic comparison of impulses generated from typical .22 and .32 caliber starter pistols firing blanks were made to impulses generated from comparable firearms firing both blanks and live ...
Deanna K, Meinke, Donald S, Finan, Jacob, Soendergaard, Gregory A, Flamme, William J, Murphy, James E, Lankford, Michael, Stewart   +6 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

新型脉动发生机构研究及运动仿真

Jixie chuandong, 2006
Structural characteristics and kinematics feature of a new impulse generator are analyzed. The relations of theoretical outline of cam, swing angle of rocker and dimension of link are established.
杨刚, 刘开昌, 黄良拾, 于海蒂, 张敬钦   +4 more
doaj  

Grid connection method of gravity energy storage generator motor based on voltage index sensitivity analysis

Energy Informatics
The basic requirements for the grid connection of the generator motor of the gravity energy storage system are: the phase sequence, frequency, amplitude, and phase of the voltage at the generator end and the grid end must be consistent.
Qingshan Wang, Yan Li, Qun Zhang, Darui He   +3 more
doaj   +1 more source

Nd-Fe-B permanent magnet generator and voltage stabilizing control technology for vehicles

Advances in Mechanical Engineering, 2016
In this study, the tangential magnetic field Nd-Fe-B permanent magnet generator is designed and analyzed. In the generator, the adjacent permanent steel is sequentially arranged on the radial groove by the way of same polarity-oriented manner.
Xueyi Zhang, Qinjun Du, Chao Ma, Shilun Ma, Jinbin Xu, Huihui Geng, Guangdong Tian   +6 more
doaj   +1 more source