Results 71 to 80 of about 6,984 (265)

Impulsive control of a nuclear spin generator

Journal of Computational and Applied Mathematics, 2003
Impulsive control of a nuclear spin generator is considered. Let be \[ X^T= (X_1,X_2,X_3),\qquad A= \begin{pmatrix} -\beta & 1 & 0\\ -1 &\beta(\gamma- 1) & 0\\ 0 & 0 & -\alpha\beta\end{pmatrix}, \] \[ \Phi(X)= \beta\gamma\begin{pmatrix} 0\\ -X_2 X_3\\ X^2_2\end{pmatrix},\qquad \alpha\in (0,1],\quad \beta,\gamma\in \mathbb{R}_+. \] The impulsive control
Sun, Jitao, Zhang, Yinping
openaire   +2 more sources

Effective Simulation Approach for Lightning Impulse Voltage Tests of Reactor and Transformer Windings

Energies, 2020
In this paper, an effective simulation method for lightning impulse voltage tests of reactor and transformer windings is presented. The method is started from the determination of the realized equivalent circuit of the considered winding in the wide ...
Piyapon Tuethong, Peerawut Yutthagowith, Anantawat Kunakorn   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Periodic Solutions Generated by Impulses for State-Dependent Impulsive Differential Equation [PDF]

Discrete Dynamics in Nature and Society, 2015
We study the existence of periodic solutions for a class of state-dependent impulsive differential systems via geometrical analysis methods. Our results show that these periodic solutions are generated by impulses. Moreover, numerical simulations are used to examine the existence of the periodic solutions.
Qizhen Xiao, Binxiang Dai
openaire   +3 more sources

High magnetic field generator of sub-microsecond duration / Mikrosekundinės trukmės magnetinių impulsų generatorius

Mokslas: Lietuvos Ateitis, 2012
The article describes the possibility of generating a micro and sub-microsecond magnetic impulse reaching 1–10 T, investigates various configurations of microcoils and discusses the principal circuit of a magnetic field impulse generator of microsecond ...
Audrius Grainys
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A General Class of Impulsive Evolution Equations

Topological Methods in Nonlinear Analysis, 2015
One of the novelty of this paper is the study of a general class of impulsive differential equations, which is more reasonable to show dynamics of evolution processes in Pharmacotherapy. This fact reduces many difficulties in applying analysis methods and techniques in Bielecki's normed Banach spaces and thus makes the study of existence and uniqueness
Fečkan, Michal, Wang, JinRong
openaire   +3 more sources