Results 51 to 60 of about 7,055 (265)

Improving the performance of LOX/kerosene upper stage rocket engines

open access: yesPropulsion and Power Research, 2017
Improved liquid rocket engine cycles were proposed and analyzed via comparison with existing staged combustion and gas-generator cycles. The key features of the proposed cycles are regenerative cooling of thrust chamber by oxygen and subsequent use of ...
IgorN. Nikischenko   +2 more
doaj   +1 more source

Acoustic Sounding of Hydraulic Fractures in a Low-Permeability Reservoir

open access: yesMathematics, 2022
Theoretical models indicate the possibility of diagnosing the presence and the conductivity of the hydraulic fractures in reservoirs of the permeability of order milli Darcy by means of an acoustic TV set, which is a cylindrical probe of the length of ...
Vladislav Sh. Shagapov   +2 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Employment of mud-pulse generator for improvement of efficiency of a wellbore producing in complex mining and geological conditions

open access: yesPetroleum Research
In this study, the employment of mud-pulse generators to improve the efficiency of wellbores under complex mining and geological conditions is examined. A systemic analysis is made of the primary theoretical basis of the study.
Bibinur Akhymbayeva
doaj   +1 more source

Influence of the Residual Inductance of the Impulse Generator for the Generation of the Lightning Impulse Voltage

open access: yesIEEJ Transactions on Power and Energy, 2007
This paper describes the theoretical analysis of lightning impulse voltage waveform with an overshoot or oscillation caused by the residual inductance of the impulse generator. The oscillating lightning impulse waveform is expressed by the following formula;vout (t) = A {e-α1t - e-α2t sin(ωt+θ)/sinθ}where A, α1, α2, ω, θ are constants, respectively ...
openaire   +2 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

GENERATION AND SPATIAL PROPAGATION OF LANDSLIDE GENERATED IMPULSE WAVES [PDF]

open access: yesCoastal Engineering Proceedings, 2017
Large subaerial mass wasting into water may generate large waves along coast lines and in bays. Hazard assessment of such an events is based on the decay rate of these impulse waves along their propagation path to populated areas and infrastructure along the shoreline.
Frederic M Evers, Willi H Hager
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Effective Simulation Approach for Lightning Impulse Voltage Tests of Reactor and Transformer Windings

open access: yesEnergies, 2020
In this paper, an effective simulation method for lightning impulse voltage tests of reactor and transformer windings is presented. The method is started from the determination of the realized equivalent circuit of the considered winding in the wide ...
Piyapon Tuethong   +2 more
doaj   +1 more source

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