Results 51 to 60 of about 966,415 (249)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
HIGH VOLTAGE DIVIDER DNV-140I FOR INFORMATION-MEASURING SYSTEMS
Надежность и качество сложных систем, 2022 Background. The relevance of the use of high-voltage voltage dividers in information-measuring systems for monitoring and measuring impulse voltages is determined by the use of various electrical equipment and capable of withstanding exposure and ...
A.S. Ilin, I.A. Karchev, A.P. Voronov
doaj +1 more source
Breakdown process on rod–rod air gap under oscillating lightning impulse voltage
High Voltage, 2020 This study presents the discharge process on rod–rod electrodes under oscillating lightning impulse voltage. For this purpose, a measurement system has been developed to record the discharge currents at both rod electrodes simultaneously and to ...
Akif Gürlek
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Impulse ageing of polymeric materials
, 2011 Impulse over-voltage is a common phenomenon in electric power systems. A switching impulse is created by a switching surge or local fault while a lightning impulse is due to direct lightning strike to high voltage plant such as an overhead line.
Dao, Ngoc Long
core +1 more source
Energies, 2020 This paper presents an effective technique based on an artificial neural network algorithm utilized for circuit parameter identification in lightning impulse generation for low inductance loads such as low voltage windings of a power transformer, a large
Piyapon Tuethong +3 more
doaj +1 more source
High‐altitude tunnel‐catenary gap impulse discharge characteristics and breakdown voltage correction
High Voltage, 2023 Air gap impulse discharge characteristics of railway tunnel‐catenary at high‐altitude are of great significance to the electrical insulation design. The existing altitude correction methods for non‐uniform air gaps are not applicable to tunnel‐catenary ...
Yi Liao +7 more
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Study on the optimisation of the end fittings of the DC disconnector
The Journal of Engineering, 2019 The disconnector is the key electrical equipment in DC field. In China, the ±1100 kV DC project uses the indoor DC field, where the switching impulse withstand voltage of the disconnector influences the clearance a lot.
Jindi Li +4 more
doaj +1 more source
High Voltage, 2022 The roof arrester of electric multiple units (EMU) can efficiently limit the overvoltage, and ensure the safe operation of the EMU electrical equipment.
Qizhe Zhang +5 more
doaj +1 more source