Results 51 to 60 of about 984,438 (297)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Lightning Impulse Ageing of HDPE
, 2009 This work is concerned with the hypothesis that lightning impulses can lead to accelerated ageing of extruded polymeric cables. The behaviour of an insulation material when suffering lightning impulses is different from that for DC or power frequency ...
Dao, N L, Swingler, S G, Lewin, P L
core +1 more source
Tower Air-gaps discharge characteristics and insulation coordination for UHV AC double-circuit line
The Journal of Engineering, 2019 In order to give out inverse V-type insulator tower air-gaps configuration of double-circuit UHV AC power transmission line, different distance air-gaps from high-voltage electrode to tower frame discharge tests of inverse V-string are carried out ...
Huo Feng, Nan Jing, Ye Qiming, Ma Yeming
doaj +1 more source
Equivalent circuit model of tower based on full-wave analysis
Energy Reports, 2022 The tower model is very important for the assessment of lightning protection for transmission line. The parameters of tower model mainly rely on the impulse experiments of tower.
Chun Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
HIGH VOLTAGE DIVIDER DNV-140I FOR INFORMATION-MEASURING SYSTEMS
Надежность и качество сложных систем, 2022 Background. The relevance of the use of high-voltage voltage dividers in information-measuring systems for monitoring and measuring impulse voltages is determined by the use of various electrical equipment and capable of withstanding exposure and ...
A.S. Ilin, I.A. Karchev, A.P. Voronov
doaj +1 more source
Breakdown process on rod–rod air gap under oscillating lightning impulse voltage
High Voltage, 2020 This study presents the discharge process on rod–rod electrodes under oscillating lightning impulse voltage. For this purpose, a measurement system has been developed to record the discharge currents at both rod electrodes simultaneously and to ...
Akif Gürlek
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Impulse ageing of polymeric materials
, 2011 Impulse over-voltage is a common phenomenon in electric power systems. A switching impulse is created by a switching surge or local fault while a lightning impulse is due to direct lightning strike to high voltage plant such as an overhead line.
Dao, Ngoc Long
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Energies, 2020 This paper presents an effective technique based on an artificial neural network algorithm utilized for circuit parameter identification in lightning impulse generation for low inductance loads such as low voltage windings of a power transformer, a large
Piyapon Tuethong +3 more
doaj +1 more source