Results 41 to 50 of about 18,526 (261)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
High Voltage, 2019 Space charge injected into a liquid dielectric by an electrode under an impulse voltage causes the electric field to be distorted, which affects the dielectric's insulation performance.
Shilin Wu +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
High VoltageIn modern power transmission systems, AC cables are increasingly integrated with overhead lines, forming hybrid networks. These cables are frequently exposed to repeated impulse voltages from the overhead lines.
Yunpeng Zhan +7 more
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Tower Air-gaps discharge characteristics and insulation coordination for UHV AC double-circuit line
The Journal of Engineering, 2019 In order to give out inverse V-type insulator tower air-gaps configuration of double-circuit UHV AC power transmission line, different distance air-gaps from high-voltage electrode to tower frame discharge tests of inverse V-string are carried out ...
Huo Feng, Nan Jing, Ye Qiming, Ma Yeming
doaj +1 more source
Energy Reports, 2022 Large-capacity impulse test of distribution transformer requires a large amount of instantaneous energy, while the impulse mode of conventional dedicated high-voltage line and generator requires synchronous switch, adjusted impedance, generator, etc ...
Bo Niu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2017 Lightning voltage impulse due to the waves of storm surge rolling out the high voltage line to a substation causes current to flow in the buses that, due to magnetic effect, induces overvoltage in the secondary circuit.
V. I. Glushko, E. A. Deryugina
doaj +1 more source
Equivalent circuit model of tower based on full-wave analysis
Energy Reports, 2022 The tower model is very important for the assessment of lightning protection for transmission line. The parameters of tower model mainly rely on the impulse experiments of tower.
Chun Li +6 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source