Results 81 to 90 of about 45,861 (261)

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco   +8 more
wiley   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

open access: yesBiological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater   +12 more
wiley   +1 more source

Exponential Quasi-Synchronization of Fractional-Order Fuzzy Cellular Neural Networks via Impulsive Control

open access: yesFractal and Fractional
This paper investigates the exponential quasi-synchronization of fractional-order fuzzy cellular neural networks with parameters mismatch via impulsive control.
Yiyao Zhang   +4 more
doaj   +1 more source

Sustaining Circular Innovation Under Volatile Market Conditions: The Critical Role of Industry Platforms

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT While industry platforms are widely recognized as enablers of circular innovation, we still know little about how they evolve to scale and sustain innovation as economic conditions tighten and circular economy funding schemes become more selective.
Eva Qi Wang   +3 more
wiley   +1 more source

Integrating Products, Processes, and Sourcing for Eco‐Innovation

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT Eco‐innovation research has often examined regulatory or technological drivers but has paid limited attention to how long‐term organizational change shapes eco‐innovation in mature, resource‐intensive industries. This study addresses that gap by investigating how two leading Finnish pulp and paper firms integrated product, process, and ...
Misa Bakajic, Anand Nair, Markku Kuula
wiley   +1 more source

Anxiety and Aggression Among College Students With High‐Risk Adverse Childhood Experiences: The Role of Bullying Perpetration

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT This study examines the potential associations between anxiety and aggressive behaviors in college students with high‐risk adverse childhood experiences (ACEs) and explores how this relationship may be influenced by bullying perpetration, applying general strain theory. A sample of 282 college students aged 19 to 29 (Mage = 21.59, SDage = 2.48;
Jeoung Min Lee   +5 more
wiley   +1 more source

Advanced glucose control strategies leveraging Raman spectroscopy for optimized mammalian cell culture manufacturing

open access: yesBiotechnology Progress, EarlyView.
Abstract Maintaining consistent quality in the manufacturing of biotherapeutic proteins in mammalian cell culture is challenging, with unplanned deviations causing inconsistencies and potential batch failure. Current methods for monitoring and controlling critical process parameters (CPPs) rely on slow, labor‐intensive offline analyses.
Matthew Banner   +12 more
wiley   +1 more source

Exponential Stabilization of Impulsive Switched Systems with Time Delays Using Guaranteed Cost Control

open access: yesAbstract and Applied Analysis, 2014
This paper investigates the stabilization problem for impulsive switched systems with time delays. First, exponential stability criteria of the delayed impulsive switched systems are established by use of the Lyapunov-Krasovskii functional method.
Xiang Xie, Honglei Xu, Rong Zhang
doaj   +1 more source

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