Results 81 to 90 of about 2,366 (263)

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Resonance phenomena in the second differential order equations with nonlinear impulsive effects

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we discuss the resonance phenomena in linear and weakly nonlinear impulsive differential equations. Using a topological approach, we obtain the Landesman–Lazer type necessary and sufficient conditions for the existence of periodic ...
Fanfan Chen, Dingbian Qian, Nannan Xu
doaj   +1 more source

Poincaré Map and Periodic Solutions of First-Order Impulsive Differential Equations on Moebius Stripe

Abstract and Applied Analysis, 2013
This paper is mainly concerned with the existence, stability, and bifurcations of periodic solutions of a certain scalar impulsive differential equations on Moebius stripe.
Yefeng He, Yepeng Xing
doaj   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Piecewise weighted pseudo almost periodic solutions of impulsive integro-differential equations via fractional operators

Electronic Journal of Differential Equations, 2015
In this article, we show sufficient conditions for the existence, uniqueness and attractivity of piecewise weighted pseudo almost periodic classical solution of nonlinear impulsive integro-differential equations.
Zhinan Xia, Dingjiang Wang
doaj  

Investigation of a Mild Solution to Coupled Systems of Impulsive Hybrid Fractional Differential Equations

International Journal of Differential Equations, 2019
The study of coupled systems of hybrid fractional differential equations requires the attention of scientists for the exploration of their different important aspects.
Mohamed Hannabou, Hilal Khalid
doaj   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

On Some New Impulsive Integral Inequalities

Journal of Inequalities and Applications, 2008
We establish some new impulsive integral inequalities related to certain integral inequalities arising in the theory of differential equalities. The inequalities obtained here can be used as handy tools in the theory of some classes of impulsive ...
Jianli Li
doaj   +1 more source

Integrating Products, Processes, and Sourcing for Eco‐Innovation

Business Strategy and the Environment, EarlyView.
ABSTRACT Eco‐innovation research has often examined regulatory or technological drivers but has paid limited attention to how long‐term organizational change shapes eco‐innovation in mature, resource‐intensive industries. This study addresses that gap by investigating how two leading Finnish pulp and paper firms integrated product, process, and ...
Misa Bakajic, Anand Nair, Markku Kuula
wiley   +1 more source