Results 121 to 130 of about 2,439,766 (250)

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

Theory and applications of first-order systems of Stieltjes differential equations

Advances in Nonlinear Analysis, 2017
We set up the basic theory of existence and uniqueness of solutions for systems of differential equations with usual derivatives replaced by Stieltjes derivatives.
Frigon Marlène, Pouso Rodrigo López
doaj   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

Regularity and Stochasticity of Nonlinear Dynamical Systems

, 2017
This book presents recent developments in nonlinear dynamics and physics with an emphasis on complex systems. The contributors provide recent theoretic developments and new techniques to solve nonlinear dynamical systems and help readers understand ...
Akhmet, Marat, Kivilcim, Aysegul, Volchenkov, Dimitri.editor.(orcid)0000-0002-3378-365Xhttps://orcid.org/0000-0002-3378-365Xedthttp://id.loc.gov/vocabulary/relators/edt, Xavier Leoncini, SpringerLink (Online service), Dimitri Volchenkov, Leoncini, Xavier.editor.edthttp://id.loc.gov/vocabulary/relators/edt   +6 more
core   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Oscillation for Forced Second-Order Impulsive Nonlinear Dynamic Equations on Time Scales

Discrete Dynamics in Nature and Society, 2019
As the unification and development of impulsive differential equations and difference equations, impulsive dynamic equations on time scales are a powerful tool to simulate the natural and social phenomena. In this paper, we study the interval oscillation
Mugen Huang, Kunwen Wen
doaj   +1 more source

GlycoMAC: A Multiscale Metabolic‐Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, and macroscopic scales to predict how inputs shape bioprocess ...
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei, Wei Xie   +3 more
wiley   +1 more source

Integrating Products, Processes, and Sourcing for Eco‐Innovation

Business Strategy and the Environment, EarlyView.
ABSTRACT Eco‐innovation research has often examined regulatory or technological drivers but has paid limited attention to how long‐term organizational change shapes eco‐innovation in mature, resource‐intensive industries. This study addresses that gap by investigating how two leading Finnish pulp and paper firms integrated product, process, and ...
Misa Bakajic, Anand Nair, Markku Kuula
wiley   +1 more source

Greenwashing or Sustainability Misalignment? Analysing Organisational, Workplace and Real Estate Strategies Through an Iceberg Lens

Business Strategy and the Environment, EarlyView.
ABSTRACT Environmental sustainability and the broader Environmental, Social and Governance (ESG) agenda have become prominently proclaimed organisational priorities, yet their integration into core decision‐making remains uneven. While greenwashing research has largely focused on communication and disclosure, it has paid less attention to the internal ...
Olayiwola Oladiran, Paul Hallam, Shilpa Taneja, Henrie Westlake, Mohammed Abbas   +4 more
wiley   +1 more source