Results 111 to 120 of about 1,913,474 (297)

Nonlinear Impulsive Multi-Order Caputo-Type Generalized Fractional Differential Equations with Infinite Delay

, 2019
We establish sufficient conditions for the existence of solutions for a nonlinear impulsive multi-order Caputo-type generalized fractional differential equation with infinite delay and nonlocal generalized integro-initial value conditions.
Ravi P. Agarwal, Bashir Ahmad, Madeaha Alghanmi, Ahmed Alsaedi   +3 more
core   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Resonance phenomena in the second differential order equations with nonlinear impulsive effects

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we discuss the resonance phenomena in linear and weakly nonlinear impulsive differential equations. Using a topological approach, we obtain the Landesman–Lazer type necessary and sufficient conditions for the existence of periodic ...
Fanfan Chen, Dingbian Qian, Nannan Xu
doaj   +1 more source

Poincaré Map and Periodic Solutions of First-Order Impulsive Differential Equations on Moebius Stripe

Abstract and Applied Analysis, 2013
This paper is mainly concerned with the existence, stability, and bifurcations of periodic solutions of a certain scalar impulsive differential equations on Moebius stripe.
Yefeng He, Yepeng Xing
doaj   +1 more source

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Piecewise weighted pseudo almost periodic solutions of impulsive integro-differential equations via fractional operators

Electronic Journal of Differential Equations, 2015
In this article, we show sufficient conditions for the existence, uniqueness and attractivity of piecewise weighted pseudo almost periodic classical solution of nonlinear impulsive integro-differential equations.
Zhinan Xia, Dingjiang Wang
doaj  

Investigation of a Mild Solution to Coupled Systems of Impulsive Hybrid Fractional Differential Equations

International Journal of Differential Equations, 2019
The study of coupled systems of hybrid fractional differential equations requires the attention of scientists for the exploration of their different important aspects.
Mohamed Hannabou, Hilal Khalid
doaj   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

On Some New Impulsive Integral Inequalities

Journal of Inequalities and Applications, 2008
We establish some new impulsive integral inequalities related to certain integral inequalities arising in the theory of differential equalities. The inequalities obtained here can be used as handy tools in the theory of some classes of impulsive ...
Jianli Li
doaj   +1 more source