Results 131 to 140 of about 1,670,423 (318)

Upper and lower solutions methods for impulsive Caputo-Hadamard fractional differential inclusions

Electronic Journal of Differential Equations, 2019
In this article we use the method of lower and upper solutions combined with the fixed point theorem by Bohnnenblust-Karlin to show the existence of solutions for initial-value problems of impulsive Caputo-Hadamard fractional differential inclusions ...
Farida Belhannache, Samira Hamani, Johnny Henderson   +2 more
doaj  

EXISTENCE RESULTS ON IMPULSIVE STOCHASTIC FUNCTIONAL DIFFERENTIAL INCLUSIONS WITH DELAYS

, 2020
. This article presents the results on existence of mild solutions for impulsive stochastic differential inclusions under sufficient conditions.
A Vinodkumar, A Anguraj, Y K Chang
core  

A Method for Optical Quantification of Local Oxygen Limitations in Multiphase Bioreactors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Spatial oxygen limitation is a major source of physiological stress and metabolic, scale‐dependent heterogeneity in aerobic bioprocesses. In gas‐liquid stirred tank reactors, oxygen availability is governed by hydrodynamics and mass transfer and is therefore inherently non‐uniform.
Ryan Rautenbach, Katharina Zörner, Jonas Barczyk, Marko Hoffmann, Ralf Takors, Michael Schlüter   +5 more
wiley   +1 more source

Mild Solutions for w-Weighted, Φ-Hilfer, Non-Instantaneous, Impulsive, w-Weighted, Fractional, Semilinear Differential Inclusions of Order μ ∈ (1, 2) in Banach Spaces

Fractal and Fractional
The aim of this work is to obtain novel and interesting results for mild solutions to a semilinear differential inclusion involving a w-weighted, Φ-Hilfer, fractional derivative of order μ∈(1,2) with non-instantaneous impulses in Banach spaces with ...
Z. Alsheekhhussain, Ahmad Gamal Ibrahim, M. M. Al-sawalha, Khudhayr A. Rashedi   +3 more
semanticscholar   +1 more source

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

Model‐Driven Monitoring and Parameter‐Based Development of an Escherichia coli Fed‐Batch Process for Production of a Fab Antibody Fragment Across Scales

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Maintaining consistent cellular physiology during bioprocess scale‐up or scale‐down is key to developing robust processes. However, the reliability of scale‐down bioreactor systems remains debated. Although the calibration of physiological parameters in mechanistic models across scales has been proposed as a scale‐down strategy, few studies ...
Fabian Schröder‐Kleeberg, Lucas Kaspersetz, Markus Zoellkau, Markus Glaser, Markus Brunner, Christian Bosch, Annina Kemmer, M. Nicolas Cruz Bournazou, Peter Neubauer   +8 more
wiley   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Stability of solutions of linear impulsive differential inclusions [PDF]

, 2004
Для лiнiйних диференцiальних включень з iмпульсами у фiксованi моменти часу встановлено умови єдиностi R-розв’язкiв. Доведено теореми про стiйкiсть розв’язкiв i R-розв’язкiв для однорiдних включень.We find uniqueness conditions for R-solutions of linear
Плотникова, Н.В.
core   +1 more source

GlycoMAC: A Multiscale Metabolic‐Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a single scale. Here, we present a multiscale mechanistic framework linking molecular, cellular, and macroscopic scales to predict how inputs shape bioprocess ...
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei, Wei Xie   +3 more
wiley   +1 more source