Results 81 to 90 of about 572 (257)

Periodic solution for second-order impulsive differential inclusions with relativistic operator

Boundary Value Problems, 2018
In this paper, the boundary value problem of a second-order impulsive differential inclusion involving a relativistic operator is studied. First, the singular problem is reduced to an equivalent non-singular problem in order to better apply the ...
Suiming Shang, Zhanbing Bai, Yu Tian, Yue Yue   +3 more
doaj   +1 more source

Impulsive fractional differential inclusions with flux boundary conditions

Filomat, 2017
In this work we investigate some existence results for solutions of a boundary value problem for impulsive fractional differential inclusions supplemented with fractional flux boundary conditions by applying Bohnenblust-Karlin?s fixed point theorem for multivalued maps.
openaire   +3 more sources

A Method for Optical Quantification of Local Oxygen Limitations in Multiphase Bioreactors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Spatial oxygen limitation is a major source of physiological stress and metabolic, scale‐dependent heterogeneity in aerobic bioprocesses. In gas‐liquid stirred tank reactors, oxygen availability is governed by hydrodynamics and mass transfer and is therefore inherently non‐uniform.
Ryan Rautenbach, Katharina Zörner, Jonas Barczyk, Marko Hoffmann, Ralf Takors, Michael Schlüter   +5 more
wiley   +1 more source

Set-valued solutions to impulsive differential inclusions [PDF]

Mathematical and Computer Modelling of Dynamical Systems, 2005
This paper deals with the state estimation problem for impulsive control systems described by differential inclusions with measures. The problem is studied under uncertainty conditions with set-membership description of uncertain variables which are taken to be unknown but bounded with given bounds.
openaire   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Existence and Controllability Results for Nonlocal Fractional Impulsive Differential Inclusions in Banach Spaces

Journal of Function Spaces and Applications, 2013
We firstly deal with the existence of mild solutions for nonlocal fractional impulsive semilinear differential inclusions involving Caputo derivative in Banach spaces in the case when the linear part is the infinitesimal generator of a semigroup not ...
JinRong Wang, Ahmed G. Ibrahim
doaj   +1 more source

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

Scalable Separation and Purification of M13‐Bacteriophage‐Derived Particles Containing Artificial Single‐Stranded DNA Produced by Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Single‐stranded DNA (ssDNA) solutions are promising innovations shaping the future of genetic research and medical therapies. In principle, biotechnological mass production of ssDNA can be achieved using Escherichia coli in a high‐cell density fed‐batch process by secreting phagemid particles derived from the filamentous M13 bacteriophages ...
Nathalie Hafner, Wiebke Winkler, Maximilian N. Honemann, Hendrik Dietz, Dirk Weuster‐Botz   +4 more
wiley   +1 more source

Existence of solutions to fractional-order impulsive hyperbolic partial differential inclusions

Electronic Journal of Differential Equations, 2014
In this article we use the upper and lower solution method combined with a fixed point theorem for condensing multivalued maps, due to Martelli, to study the existence of solutions to impulsive partial hyperbolic differential inclusions at fixed ...
Said Abbas, Mouffak Benchohra
doaj