Results 71 to 80 of about 1,371 (244)

Cognitive and behavioral clinical outcome assessments in children with developmental and epileptic encephalopathies: Issues and instruments

Epilepsia, EarlyView.
Abstract Children with developmental and epileptic encephalopathies (DEEs) face cognitive and behavioral challenges that may have a greater impact than seizures on their quality of life (QoL). The need to assess these nonseizure outcomes for evaluating treatments is increasingly recognized.
Cinzia Correale, Nicola Specchio, Jenny Downs, J. Helen Cross, Simona Cappelletti, Andrea Palacio‐Navarro, Sam Geuens, Kette Valente, Andreas Brunklaus, Colin Reilly   +9 more
wiley   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Weak‐Story Mitigation and Drift Redistribution in Moment‐Resisting Frames Using Stepping Rocking Walls

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT This study investigates the seismic response of moment‐resisting frames retrofitted with a stepping rocking wall, with emphasis on weak‐story mitigation and residual drift reduction under both ordinary and pulse‐like ground motions. Nonlinear response‐history analyses are conducted on 9‐story and 20‐story SAC Los Angeles frames.
Mehrdad Aghagholizadeh
wiley   +1 more source

Learning Rocking Dynamics From Sparse Shake‐Table Data With Interpretable Physics‐Informed Neural Networks

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT We present a hybrid interpretable Physics‐Informed Neural Network Long‐Short Term Memory (Hybrid PINN LSTM) framework for predicting the seismic response of rocking blocks. Existing analytical models rely on uncertain idealizations, while purely data‐driven and machine‐learning approaches lack physical consistency and interpretability.
Shirley Shen, Christian Málaga‐Chuquitaype   +1 more
wiley   +1 more source

Energy‐Based Characterisation of Earthquake Damage in Masonry Infills Through Combined In‐Plane and Out‐of‐Plane Experimental Tests

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT The seismic capacity of structural systems/members is usually defined in terms of deformation thresholds. Although this is effective in many circumstances, disregarding cumulative quantities such as hysteretic energy may be ineffective when low‐cycle fatigue is relevant (e.g., long‐duration ground motions, very soft soils, ground‐motion ...
Roberto Gentile, Giulia Angelucci, Jingren Wu, Marilisa Di Benedetto, Riccardo Milanesi, Giulio Augusto Tropea, Fabrizio Mollaioli, Fatemeh Jalayer, Fabio Freddi, Fabio Di Trapani, Paolo Morandi, Gerard J. O'Reilly   +11 more
wiley   +1 more source

Impulsive functional differential equations with variable times

Computers & Mathematics with Applications, 2004
The authors investigate the existence of solutions to a first-order retarded functional-differential equation with impulses. The case including higher-order equations and studied by the same authors can be found in [Dyn. Syst. Appl. 12, No. 3--4, 383--392 (2003; Zbl 1073.34092)].
Benchohra, M., Henderson, J., Ntouyas, S.K., Ouahab, A.   +3 more
openaire   +1 more source

Identifying Affective Patterns in Patients With Eating Disorders: A Latent Profile Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Background Emotional difficulties are common among individuals with Eating Disorders (EDs). Following Panksepp's theoretical model, which conceptualises primary emotional systems as the evolutionary foundation of personality, this study aimed to identify distinct profiles of primary emotional systems within a clinical eating disorder (ED ...
Rachele Fasolato, Chiara Bonetto, Rosa Bruna Dall’Agnola, Emily Boifava, Federica Bonora, Mariasole Castellazzi, Silvia Castelli, Doriana Cristofalo, Silvia Danese, Monica Ferlin, Stuart B. Murray, Martina Puglisi, Silvia Rigon, Antonio Elia Rizzo, Benedetta Signoretto, Corrado Barbui   +15 more
wiley   +1 more source

Recent advances in multifunctional soft robots: A materials–structures–systems co‐design perspective for synergistic integration

FlexMat, EarlyView.
Abstract Soft robots, engineered from highly compliant materials, offer superior adaptability and safety in unstructured environments compared to their rigid counterparts. Recent advancements, fueled by bio‐inspiration and material programmability, have led to the rapid co‐evolution of their core modules: actuation, sensing, protection, energy, and ...
Qiulei Liu, Zicao Peng, Chong Sun, Haitao Yang   +3 more
wiley   +1 more source

Exploring the Value Realization and Management of Healthcare Data Elements in the Context of New Quality Productive Forces

Health Care Science, EarlyView.
With the rapid advancement of information technology, data has become a key driver of social progress, particularly in the medical field. The accumulation and innovative application of medical data have not only reshaped the structure of medical production factors but also provided a strong impetus for the development of new productivity.
Zhixuan Yu, Jiaxuan Wei, Jianlin Wang, Jie Lu, Pengfei Cao   +4 more
wiley   +1 more source

Neuroanatomical and functional correlates in borderline personality disorder: A narrative review

Ibrain, Volume 11, Issue 1, Page 19-31, Spring 2025.
Borderline personality disorder (BPD) is considered a dysfunctional, stable, and pervasive alteration in personality functioning with the inability to adapt to the environment, mental rigidity, and ego‐syntonic, and like all personality disorders is a consistent pattern of inner experience and behavior that deviates markedly from the expectations of ...
Giulio Perrotta
wiley   +1 more source