Results 151 to 160 of about 919 (260)

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

open access: yesBritish Journal of Pharmacology, EarlyView.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama   +4 more
wiley   +1 more source

The Politics of Othering in the 'Happy Soul': Historicising Abjection in the Promise of Joy for Childhood and Play

open access: yesChildren &Society, EarlyView.
ABSTRACT This article interrogates the politics of othering embedded in the taken‐for‐granted association of childhood, play, joy, and happiness. It explores how these notions are historically inscribed as forms of otherness tied to the affective normativity of joy.
Chushan Wu
wiley   +1 more source

Development and validation of the Essen Melanoma Quality of Life Inventory (EMQoLI)

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives New treatments for melanoma, such as targeted therapy and immunotherapy, present unique adverse events compared to traditional treatments like surgery and chemotherapy. Existing health‐related quality of life (HRQoL) measures often fail to address these new treatment effects and focus primarily on chemotherapy and ...
Venja Musche   +10 more
wiley   +1 more source

Spinoza on Humans as Social Animals

open access: yesEuropean Journal of Philosophy, EarlyView.
Abstract Spinoza repeatedly suggests that humans are set apart from other animals by their rational and moral abilities. Yet he disparages the traditional definition of the human as a ‘rational animal’ and several of his other views suggest that these abilities are not sufficient by themselves to characterize human nature.
Ruben Noorloos
wiley   +1 more source

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