Results 101 to 110 of about 9,376 (298)

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Impact of gas injection location and divertor surface material on ITER fusion power operation phase divertor performance assessed with SOLPS-ITER

Nuclear Fusion
The ITER divertor design and performance assessment, primarily based on the SOLPS-4.3 burning plasma database (Pitts R. et al 2019 Nucl. Mater. Energy   20 100696), assumes the use of beryllium (Be) as the divertor surface material and the injection of ...
Jae-Sun Park, Xavier Bonnin, Richard Pitts, Jeremy Lore   +3 more
doaj   +1 more source

Experimental conditions to suppress edge localised modes by magnetic perturbations in the ASDEX Upgrade tokamak

, 2018
Access conditions for full suppression of Edge Localised Modes (ELMs) by Magnetic Perturbations (MP) in low density high confinement mode (H-mode) plasmas are studied in the ASDEX Upgrade tokamak.
Bobkov, V., Cavedon, M., Dunne, M., Kirk, A., McDermott, R. M., Meyer, H., Nazikian, R., Paz-Soldan, C., Ryan, D. A., Suttrop, W., Viezzer, E., Willensdorfer, M.   +11 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Evaluation of SPARC divertor conditions in H-mode operation using SOLPS-ITER

Nuclear Fusion
The predicted divertor conditions for the SPARC tokamak are calculated using SOLPS-ITER for a range of scrape-off-layer (SOL) heat flux widths λ _q , input powers, and particle fueling locations.
Jeremy D. Lore, Jae-Sun Park, Thomas Eich, Adam Q. Kuang, Matthew L. Reinke, Sebastian De Pascuale, Bart Lomanowski, Alex Creely, John M. Canik   +8 more
doaj   +1 more source

Impurity-free seeded crystallization of amorphous silicon by nanoindentation

Journal of Applied Physics, 2011
We demonstrate that nanoindents formed in amorphous Si films, with dimensions as small as ∼20 nm, provide a means to seed solid phase crystallization. During post-indentation annealing at ∼600 °C, solid phase crystallization initiates from the indented sites, effectively removing the incubation time for random nucleation in the absence of seeds.
Ruffell, S., Knights, A. P., Bradby, J. E., Williams, J. S.   +3 more
openaire   +2 more sources

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source

EMC3-EIRENE simulations of edge plasma and impurity transport by toroidally localized argon seeding on CFETR X-divertor

Nuclear Fusion
The three-dimensional (3D) edge Monte Carlo transport code EMC3-EIRENE has been employed to study edge plasma and impurity transport with toroidally localized argon seeding using the Chinese fusion engineering testing reactor (CFETR) X-divertor ...
T. Xie, H. Li, W. Zhang, R. Ding, L. Wang, Y. Luo, D.Z. Wang   +6 more
doaj   +1 more source

Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

Advanced Science, EarlyView.
Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro, Satoshi Okada, Filippo Rossi, Takahiro Kuchimaru, Yuta Kurashina   +4 more
wiley   +1 more source