The challenges of bioprosthetic heart valves (BHV) with respect to calcification, infection, and poor durability are tackled by surface engineering of hyperbranched poly‐L‐lysine (HBPL), providing a translational solution to improve long‐term valve performance.
Pai Peng +7 more
wiley +1 more source
Chiral Resolution of Aspartic Acid Racemate by Single Crystallization With Phenylalanine as Additive. [PDF]
Xue X +5 more
europepmc +1 more source
A probiotic spore‐based drug delivery system (BCS‐Que@ApNPs) provides excellent targeted delivery, bioresponsive drug release, and long‐term retention (over 48 h), making it suitable for oral treatment of inflammatory bowel disease and its associated anxiety and depression.
Qingling Song +9 more
wiley +1 more source
Rainfall immediately before and after fire promotes long-term occurrence of a rare, fire-sensitive passerine. [PDF]
Mitchell WF +4 more
europepmc +1 more source
Purification and concentration of model viruses using single‐pass tangential flow filtration
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano +6 more
wiley +1 more source
Study on the effect of ammonium (NH<sub>4</sub><sup>+</sup>) as impurity and seed ratio on batch cooling crystallization of nickel sulfate hexahydrate. [PDF]
Andriyan MW +6 more
europepmc +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Multi-Source Perception, Intelligent Decision-Making, and Precision Control for Autonomous Agricultural Systems: A Comprehensive Review. [PDF]
Zhang S +5 more
europepmc +1 more source
Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson +7 more
wiley +1 more source
Taming harmful bursts and heat flux in high-confinement tokamak plasmas. [PDF]
Hu QM +31 more
europepmc +1 more source

