Results 121 to 130 of about 1,318,109 (301)

Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease

npj Parkinson's Disease
Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic signatures can provide novel gene candidates for use as PD biomarkers. We leveraged on the Genotype-
Gabriel Chew, A. Mai, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, E. Tan   +7 more
semanticscholar   +1 more source

Validation of a Genetic Risk Score Combined with Clinical Variables for Predicting Pulmonary Fibrosis in early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objectives Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). The study aimed to externally validate a genetic risk score (GRS) and a combined risk score for predicting the risk of RA‐associated PF in an independent cohort of early‐RA patients. Methods This study utilized an inception cohort of 1118 patients
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Sex differences in medication discontinuation in axial spondyloarthritis.

Arthritis Care &Research, Accepted Article.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or Janus kinase inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

Statistical Matching Imputation among Different Farm Data Sources

, 2017
This work addresses the challenge of integrating different data sources, dealing with both statistical methodology and a practical application to farm data. It reviews the existing literature on Statistical Matching (SM) imputation, focusing on non-parametric micro “hot deck” techniques, which reduce the bias generated by model-based integration ...
openaire   +2 more sources

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis‐Associated Interstitial Lung Disease Risk

Arthritis Care &Research, Accepted Article.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase (MMP)‐7, and serum anti‐malondialdehyde‐acetaldehyde (anti‐MAA) antibody for RA‐associated interstitial lung disease risk stratification. Methods Using a multicenter cohort of US veterans with RA, we performed a cross‐
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

GWAS summary statistics imputation support data and integration with PrediXcan MASHR

, 2019
Alvaro Barbeira, Hae Kyung Im
  +4 more sources

Moving Beyond Medical Statistics: A Systematic Review on Missing Data Handling in Electronic Health Records

Health Data Science
Background: Missing data in electronic health records (EHRs) presents significant challenges in medical studies. Many methods have been proposed, but uncertainty exists regarding the current state of missing data addressing methods applied for EHR and ...
Wenhui Ren, Zheng Liu, Yanqiu Wu, Zhilong Zhang, Shenda Hong, Huixin Liu   +5 more
semanticscholar   +1 more source

An application of a complex measure to model–based imputation in business statistics¹ [PDF]

, 2021
Andrzej Młodak
openalex   +1 more source

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Research on Missing Data Estimation Method for UPFC Submodules Based on Bayesian Multiple Imputation and Support Vector Machines

Energies
With the increasing complexity of power systems, the monitoring data of UPFC submodules suffers from high missing rates due to sensor failures and environmental interference, significantly limiting equipment condition assessment and fault warning ...
Xiaoming Yu, Jun Wang, Ke Zhang, Zhijun Chen, Ming Tong, Sibo Sun, Jiapeng Shen, Li Zhang, Chuyang Wang   +8 more
doaj   +1 more source