Results 51 to 60 of about 202,193 (268)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Improved imputation of summary statistics for admixed populations [PDF]
, 2017 AbstractMotivationSummary statistics imputation can be used to infer association summary statistics of an already conducted, genotype-based meta-analysis to higher ge-nomic resolution. This is typically needed when genotype imputation is not feasible for some cohorts.
Rüeger, Sina +2 more
openaire +1 more source
Handling Attrition in Longitudinal Studies: The Case for Refreshment Samples [PDF]
, 2013 Panel studies typically suffer from attrition, which reduces sample size and can result in biased inferences. It is impossible to know whether or not the attrition causes bias from the observed panel data alone.
Deng, Yiting +4 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Optimal class of memory type imputation methods for time-based surveys using EWMA statistics
Scientific ReportsTime-based surveys often experience missing data due to several reasons, like non-response or data collection limitations. Imputation methods play an essential role in incorporating these missing values to secure the accuracy and reliability of the ...
Anoop Kumar +2 more
doaj +1 more source
Assessing uncertainty in the American Indian Trust Fund
, 2010 Fiscal year-end balances of the Individual Indian Money System (a part of the Indian Trust) were constructed from data related to money collected in the system and disbursed by the system from 1887 to 2007.
Mulrow, Edward +2 more
core +1 more source
Analysis of Incomplete Compound Variables [PDF]
, 2015 This is the peer reviewed version of the following article: Zhao, J., Cook, R. J. and Wu, C. (2015), Multiple imputation for the analysis of incomplete compound variables. Can J Statistics, 43: 240–264. doi: 10.1002/cjs.11249, which has been published in
Agresti +33 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Data Editing and Imputation in Business Surveys Using “R” [PDF]
Revista Română de Statistică, 2014 Purpose – Missing data are a recurring problem that can cause bias or lead to inefficient analyses. The objective of this paper is a direct comparison between the two statistical software features R and SPSS, in order to take full advantage of the ...
Elena Romascanu
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source