Results 201 to 210 of about 259,056 (286)

Transrectal vs transperineal prostate biopsy: a systematic review and meta‐analysis

open access: yesBJU International, EarlyView.
Objective To compare transrectal ultrasonography (TRUS) and local anaesthetic transperineal (LATP) biopsy. Methods A systematic review of randomised control trials and prospective studies meeting eligibility criteria was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Results A total of 12
Gavin G. Calpin   +8 more
wiley   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Student Perceptions of 360o (3D) Imaged‐Models Used for Fixed Prosthodontics Simulation Education: Enhancing Visualisation, Understanding and Self‐Assessment

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Introduction This study evaluated and compared the effectiveness of a novel 3D imaged models (3D IMs) and physical reference models in supporting student learning of indirect tooth preparations. Materials and Methods Fourth‐year dental students from 2021 (N = 69) and 2022 (N = 54) received access to 3D IMs and real‐sized plastic models ...
Manal Ablal   +3 more
wiley   +1 more source

Characterisation of a cold‐adapted, thermostable glucokinase from psychrophilic Pseudoalteromonas sp. AS‐131 reveals how the enzyme achieves high thermal stability without loss of cold adaptation

open access: yesThe FEBS Journal, EarlyView.
We investigated glucokinase from the psychrophilic Pseudoalteromonas sp. AS‐131 (PsGK), which was isolated from the Antarctic Ocean. Biochemical studies revealed that PsGK is a cold‐adapted enzyme with high thermal stability, in contrast to general cold‐adapted enzymes, which have low thermal stability.
Akane Yato   +10 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

open access: yesThe FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna   +5 more
wiley   +1 more source

Spatial and temporal brain biodistribution of neuropathogenic sphingolipids of Krabbe disease. [PDF]

open access: yesJ Lipid Res
Yan T   +6 more
europepmc   +1 more source

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