Results 91 to 100 of about 56,903 (296)

Boundary States for Supertubes in Flat Spacetime and Godel Universe

, 2003
We construct boundary states for supertubes in the flat spacetime. The T-dual objects of supertubes are moving spiral D1-branes (D-helices). Since we can obtain these D-helices from the usual D1-branes via null deformation, we can construct the boundary ...
B. Durin, C. Bachas, D. Brace, D. Brace, D. Brecher, D. Brecher, D. Mateos, D.S. Bak, H. Takayanagi, Hiromitsu Takayanagi, J.P. Gauntlett, K. Gödel, M. Blau, M. Kruczenski, M.R. Douglas, N. Drukker, N. Seiberg, O. Bergman, R.C. Myers, R.C. Myers, T. Takayanagi, T. Takayanagi, V.E. Hubeny, Y. Hikida   +23 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Measurement of Milwaukee Brace Pad Pressure in Adolescent Round Back Deformity Treatment [PDF]

Asian Spine Journal, 2017
Study DesignIn this prospective study, we measured the pad pressures of the Milwaukee brace in adolescent hyperkyphosis treatment.PurposeWe evaluated the skin-brace interface forces exerted by the main pads of the Milwaukee brace.Overview of LiteratureA ...
Taher Babaee, Mojtaba Kamyab, Amir Ahmadi, Mohammad Ali Sanjari, Mohammad Saleh Ganjavian   +4 more
doaj   +1 more source

Effectiveness of dynamic over static foot abduction brace and evaluation of impact of parental socioeducational status in the maintenance phase of clubfoot correction

, 2021
Objective: Foot abduction brace (FAB) plays an important role in the maintenance phase of Ponseti clubfoot management. Compliance with the bracing protocol is affected by different foot brace designs.
Pabitra K Sahoo, Maheswar Vijay, S. Das, M. Sahu, Abhisek Sanyal   +4 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Fast simulation of stabilizer circuits using a graph state representation

, 2006
According to the Gottesman-Knill theorem, a class of quantum circuits, namely the so-called stabilizer circuits, can be simulated efficiently on a classical computer. We introduce a new algorithm for this task, which is based on the graph-state formalism.
D. Schlingemann, E. N. Maneva, Hans J. Briegel, M. A. Nielsen, M. Grassl, Simon Anders   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source