Results 101 to 110 of about 56,903 (296)

Pilot Biomechanical Evaluation of Spring Ligament Augmentation with the Internal Brace in a Cadaveric Flatfoot Model

Foot & Ankle Orthopaedics, 2018
Category: Hindfoot Introduction/Purpose: Surgical reconstruction for flexible acquired flatfoot deformity from posterior tibial tendon dysfunction has been described and often includes a medial displacing calcaneal osteotomy (MDCO), Flexor digitorum ...
Michael Aynardi MD, Kaitlin Saloky BS, Paul Juliano MD, Gregory Lewis PhD   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

216 Jewish Hospital of St. Louis [PDF]

, 1970
https://digitalcommons.wustl.edu/bjc_216/1105/thumbnail ...

core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

HOW EFFECTIVE IS STEENBEEKS BRACE IN MAINTAINING CORRECTION IN CLUBFOOT AFTER PONSETI TREATMENT

, 2023
S.M.G. Raza and Jitendra Kumar Tripathi Ashok Vidyarthi
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Optimized braces for the treatment of adolescent idiopathic scoliosis: A study protocol of a prospective randomised controlled trial.

PLoS ONE
IntroductionAdolescent Idiopathic Scoliosis (AIS) is a 3D deformity of the spine that affects 3% of the adolescent population. Conservative treatments like bracing aim to halt the progression of the curve to the surgical threshold.
Maxence Coulombe, Aymeric Guy, Soraya Barchi, Hubert Labelle, Carl-Éric Aubin   +4 more
doaj   +1 more source

A chart of certain skills in written communication for grades seven to twelve [PDF]

, 1958
Thesis (Ed.M.)--Boston ...
Blake, Ernest Raymond, Jr.
core   +1 more source

Deformation of the Fermi Surface and Anomalous Mass Renormalization by Critical Spin Fluctuations through Asymmetric Spin-Orbit Interaction

, 2015
It is shown that an asymmetric spin-orbit interaction is appreciably renormalized by the effect of critical spin fluctuations. As an explicit example, the Rashba-type interaction is predicted to be suppressed by anti-ferromagnetic critical fluctuations ...
Fujimoto, Yukinobu, Matsuura, Hiroyasu, Miyake, Kazumasa   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source