Results 81 to 90 of about 76,480 (341)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Arab identity and attitudes toward migration in Kuwait and Qatar

Research & Politics, 2023
This paper explores the attitudes of expatriate workers towards the future of migration to the Arab Gulf states. We conduct an online survey and framing experiment administered to more than 2900 expatriate workers in Kuwait and Qatar.
Lisa Blaydes, Justin Gengler
doaj   +1 more source

A question of value(s): Political connectedness and executive compensation in public sector organizations [PDF]

, 2018
While the de-politicization of public sector management was a core objective of past reform initiatives, more recent debates urge the state to act as a strong principal when it comes to public sector unity and policy coherence - and consequently make a ...
Höllerer, Markus, Leixnering, Stephan, Meyer, Renate   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

INTERGROUP PERCEPTION OF AUTHORITIES AND POLITICAL OPPOSITION SUPPORTERS

Вестник Кемеровского государственного университета, 2015
The paper covers the results of research of intergroup perception in the context of supporting of authorities. The author presents verbal portraits of authorities supporters and political opposition supporters in terms of in-group and outgroup beliefs ...
S. F. Akhmatnurova
doaj  

Ingroup favoritism in cooperation in a dynamic intergroup context: Data from Israeli professional volleyball players

Judgment and Decision Making
Past research has documented ingroup favoritism, the tendency to cooperate more with ingroup members than outgroup members, in a wide range of intergroup contexts, and extensively discussed conditions under which ingroup favoritism emerges.
Hirotaka Imada, Rebecca Kopilovitch, Roʿi Zultan   +2 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

When the black sheep is not so «black». Social comparison as a standard for ingroup evaluation in classrooms [PDF]

, 2017
Previous research (Marques & Levine, 2016) suggests that the black sheep effect refers to the tendency of people to evaluate ingroup deviants members more negatively than outgroup deviants members. School students (N = 60) evaluated negative and positive
Livi, Stefano, Pantaleo, Giuseppe, Rullo, Marika, Viola, Rosita   +3 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source