Results 131 to 140 of about 274,248 (306)

Delays in Cardiopulmonary Resuscitation, Defibrillation, and Epinephrine Administration All Decrease Survival in In-hospital Cardiac Arrest

Anesthesiology, 2019
What We Already Know about This Topic Rapid response to witnessed, pulseless cardiac arrest is associated with increased survival. What This Article Tells Us That Is New Assessment of witnessed, pulseless cardiac arrests occurring at 538 hospitals during
N. Bircher, P. Chan, Yan Xu, R. Faillace, M. Mancini, R. Berg, Emilie Allen, E. Hunt, V. Nadkarni, Mary Ann Peberdy, J. Ornato, S. Braithwaite, G. Nichol, Sam A. Warren, Kathy D. Duncan, K. Labresh, C. Sasson, L. Knight, M. Donnino, Mindy Smyth, B. Eigel, L. Gent, T. Mader, K. Kern, R. Geocadin   +24 more
semanticscholar   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Design and implementation of the hospital airway resuscitation trial

Resuscitation Plus
Guidelines for the management of in-hospital cardiac arrest resuscitation are often drawn from evidence generated in out-of-hospital cardiac arrest populations and applied to the in-hospital setting.
Ari Moskowitz, Luke Andrea, Ariel L. Shiloh, John Cardasis, Colleen Carty, Mimi Kim, Xianhong Xie, Susan McAllen, David Esses, Carlo Lutz, Mai Takematsu, Jose Romero, Kristen Schimmrich, Daniel G. Fein, Amos E. Dodi, Samuel Rednor, Maneesha Bangar, Amira Mohamed, Lewis A. Eisen, Henry E. Wang, Michael W. Donnino, Michelle Ng Gong   +21 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The role of magnesium in cardiac arrest

Frontiers in Nutrition
Cardiac arrest is a leading cause of death globally. Only 25.8% of in-hospital and 33.5% of out-of-hospital individuals who achieve spontaneous circulation following cardiac arrest survive to leave the hospital.
Baoshan Liu, Baoshan Liu, Muyuan Li, Muyuan Li, Jian Wang, Jian Wang, Fengli Zhang, Fengli Zhang, Fangze Wang, Fangze Wang, Caicai Jin, Caicai Jin, Jiayi Li, Jiayi Li, Yanran Wang, Yanran Wang, Thomas Hudson Sanderson, Rui Zhang, Rui Zhang   +18 more
doaj   +1 more source

Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival

Journal of the American Medical Association (JAMA), 2017
Importance Tracheal intubation is common during adult in-hospital cardiac arrest, but little is known about the association between tracheal intubation and survival in this setting.
L. Andersen, A. Granfeldt, C. Callaway, S. Bradley, J. Soar, J. Nolan, T. Kurth, M. Donnino   +7 more
semanticscholar   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Impact of the COVID-19 pandemic on poisoning induced out of hospital cardiac arrest in South Korea retrospective observational study

Scientific Reports
Poisoning-induced out-of-hospital cardiac arrest has characteristics distinct from cardiogenic out-of-hospital cardiac arrest, with external factors such as patient intent and environmental influences playing crucial roles.
Young Taeck Oh, Chiwon Ahn, Yeonkyung Park, Jae Hwan Kim   +3 more
doaj   +1 more source