Results 171 to 180 of about 561,079 (212)
Advanced Science, EarlyView.ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin +7 more
wiley +1 more source
Targeting a Calcium‐Associated Mitochondrial Vulnerability in TET2‐Deficient Myeloid Cells
Advanced Science, EarlyView.Reduced TET2 function creates a calcium‐associated mitochondrial vulnerability in macrophages that is preferentially exploited by Lanatoside C. The resulting stress promotes apoptosis of TET2‐deficient macrophages, reduces inflammatory and fibrotic injury in human cardiac organoids, and highlights a genotype‐associated myeloid liability that may be ...
Yue Wang +18 more
wiley +1 more source
Editorial: Address risk factors as part of clinical practice to prevent stroke
South Sudan Medical JournalEluzai Abe Hakim
doaj +1 more source
Correction: Knowledge of Community General Practitioners and Nurses on Pre-Hospital Stroke Prevention and Treatment in Chongqing, China. [PDF]
PLoS One, 2019 Yang J, Zhang J, Ou S, Wang N, Wang J.
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.This review traces three decades of technological evolution in robot‐assisted fracture reduction systems, from early robotic concepts to clinically oriented platforms. Key advances in robotic architecture, navigation, path planning, interaction control, and surgical integration are summarized, while current translational challenges and future ...
Shaolong Kuang +5 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò +7 more
wiley +1 more source
AI‐Based Mitochondrial Network Characterization as a Biomarker for DNM1L‐Related Disease Diagnosis
Advanced Intelligent Systems, EarlyView.This work provides proof‐of‐concept that AI‐based analysis of mitochondrial network morphology in patient‐derived fibroblasts can identify a phenotypic signature associated with DNM1L deficiency. This automated approach may ultimately provide a complementary functional readout for the interpretation of novel DNM1L variants following genetic testing ...
Uliana Musokhranova +9 more
wiley +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Background Long COVID affects a significant proportion of COVID‐19 survivors. This study examined persistent Long COVID symptoms among healthcare personnel (HCP) and evaluated associations with vaccination, prior SARS‐CoV‐2 infection, underlying health conditions, and demographics.
Eric Kontowicz +13 more
wiley +1 more source
Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen +8 more
wiley +1 more source
Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert +31 more
wiley +1 more source