Results 91 to 100 of about 207,946 (243)

The Quadcomb: a novel zero Poisson’s ratio honeycomb structure with 2D compliance for morphing aircraft applications

Materials & Design
The Quadcomb is a new honeycomb design whose unit cell embeds slender support plates between bending ribs. This geometry simultaneously delivers bidirectional compliance with a near-zero Poisson’s ratio (∼10-2) and affords independent tailoring of out-of-
Omar Mamoun, Rafic Ajaj, Yahya Zweiri, Fabrizio Scarpa   +3 more
doaj   +1 more source

Hybrid micropixel detector at the focal plane of the mass-spectrometer [PDF]

Ядерна фізика та енергетика, 2009
Results on testing TimePix micropixel chip as a detector of low energy ions in a focal plane of the laser massspectrometer are presented. Two options were tested: hybrid micro-pixel detector as well as metal micro-pixel detector (naked read-out chip ...
M. Campbell, L. Tlustos, D. Maneuski, Val O Shea, V. Storizhko, V. Eremenko, S. Homenko, A. Shelekhov, V. Pugatch, O. Kovalchuk, A. Chaus, O. Okhrimenko, D. Storozhik   +12 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Designs of Optomechanical Acceleration Sensors with the Natural Frequency from 5 Hz to 50 kHz

Designs
In many applications, such as space navigation, metrology, testing, and geodesy, it is necessary to measure accelerations with frequencies ranging from fractions of a hertz to several kilohertz. For this purpose, optomechanical sensors are used.
Marina Rezinkina, Claus Braxmaier
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Design and Verification of a Metaphyseal Filling Stem for Total Hip Arthroplasty Based on Novel Measurements of Proximal Femoral Anatomy

Arthroplasty Today
Background: Cementless metaphyseal filling stems rely on fixation in the medial-to-lateral and anterior-to-posterior (AP) planes. The purpose of this preclinical study was to develop Insignia, a new metaphyseal filling system to match the anatomy of the ...
Victor R. Carlson, MD, Bryan D. Springer, MD, Ahmad Faizan, PhD, Joshua Peterson, PhD, Don Imami, BS, Jeremy M. Gililland, MD   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In-plane torsion test – Analysis and design of the clamps

International Journal of Material Forming
Abstract The objective of the paper is to analyze the fundamental influence of the tool design on the in-plane torsion test in order to create a common basis for carrying out tests that enable the characterization of comparable material parameters between various test setups.
Fabian Stiebert, Heinrich Traphöner, A. Erman Tekkaya   +2 more
openaire   +1 more source