Results 61 to 70 of about 117,431,911 (302)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Fatigue Reliability Analysis of Rib-To-Deck Joints Using Test Data and In-Situ Measurements

Applied Sciences, 2019
In this paper, the fatigue performance of rib-to-deck joints in orthotropic steel decks (OSDs) using thickened edge U-ribs (TEUs) and the OSD using conventional U-ribs (CUs) are investigated based on the fatigue test result and in-situ monitoring data ...
Kaifeng Zheng, Xiaoyang Feng, Junlin Heng, Jin Zhu, Yu Zhang   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

In Situ Measurement of Alkali Metals in an MSW Incinerator Using a Spontaneous Emission Spectrum

Applied Sciences, 2017
This paper presents experimental investigations of the in situ diagnosis of the alkali metals in the municipal solid waste (MSW) flame of an industrial grade incinerator using flame emission spectroscopy.
Weijie Yan, Chun Lou, Qiang Cheng, Peitao Zhao, Xiangyu Zhang   +4 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Development of in-situ SEM torsion tester for microscale materials

, 2019
An in-situ SEM (scanning electron microscope) micro-torsion tester with high resolution is developed based on electromagnetism. The torque is controlled and measured using a coil-magnet component. The torsion angle is measured by a non-contact transducer
Yang R(杨荣), Dong J, Chen B(陈博), Wang SF(王素芳), Wang J(王军), Huan Y(郇勇)   +5 more
core   +2 more sources

Study on a New Type of Annular Elliptic Finned Tube Evaporative Condenser

Zhileng xuebao, 2020
A new evaporative condenser with an annular elliptic finned tube heat exchanger (AEFTHE) was designed and theoretically analyzed in this study. The cooling water flowed inside the round inner tube, while the spray water and cooling air passed outside the
Gu Yaxiu, Wang Junwei, Liu Guangdong, Pan Song, Li Mohua, Wang Xinru   +5 more
doaj  

Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman, Mei Li, Xiudong Lei, Hui Zhao, Juan I. Ruiz, Sharon H. Giordano, Alexis R. Ogdie, Maria E. Suarez‐Almazor   +7 more
wiley   +1 more source

In Situ and Ex Situ Conservation Measures

Abstract The effects of climate change and biodiversity loss are global and not limited by national borders, with forest ecosystems, in particular, suffering under increasing pressure. To preserve and maintain species genetic diversity, well-considered in situ and ex situ measures are needed.
Barbara Fussi, Muhidin Šeho, Darius Kavaliauskas   +2 more
openaire   +1 more source