Results 51 to 60 of about 772,601 (302)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Consolidation states of silty soils in tidal flats of Yellow River estuary by in-situ testing

Yantu gongcheng xuebao
The sediments in the Yellow River estuary rapidly deposit in the estuarine area. Under the action of waves and tidal waves, the surface sediments are in an over-consolidated state.
ZHANG Jianmin 1, 2, SHAN Hongxian 3, WANG Zhenqiang 1, 2, WANG Zhicai 1, 2, WANG Jinjin 1, 2
doaj   +1 more source

Spectroscopy framework and review of characterization of energy resource sites

Energy Geoscience, 2022
Site characterization and rapid reliable identification of energy resources play a key role for future efficient energy production. Over the last several decades, many laboratory and in-situ techniques were developed to qualitatively and quantitatively ...
C. Tohm, T. Bheemasetti, P. Diwakar
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Design and Application of a Miniature Pneumatic Bellows Loading Device for In-Situ Tensile Testing inside the Scanning Electron Microscope

Metals
A miniature pneumatic bellows device was designed for in-situ testing inside the scanning electron microscope. The device uses a pneumatic actuator to load the specimen and displacement is directly monitored with a linear variable differential ...
Pekka Moilanen, Guilherme Corrêa Soares, Matti Lindroos, Andrew Roiko   +3 more
doaj   +1 more source

Reinforced concrete beams behaviour under static loads – in situ case study [PDF]

Constructii: Journal of Civil Engineering Research, 2019
Sometimes there are reinforced concrete structures for which conventional computational methods are not sufficient to demonstrate their intended use. In-situ tests are conclusive to determine the ability of a structure to support additional loads, to ...
Adrian LĂZĂRESCU, Henriette SZILÁGYI, Andreea HEGYI, Carmen DICO   +3 more
doaj  

Ecology of endolithic lichens colonizing granite in continental Antarctica [PDF]

, 2005
In this study, the symbiont cells of several endolithic lichens colonizing granite in continental Antarctica and the relationships they have with the abiotic environment were analyzed in situ, in order to characterize the microecosystems integrating ...
Ascaso, Carmen, de los Ríos, Asunción, Green, T.G. Allan, Sancho, Leopoldo G., Wierzchos, Jacek   +4 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Suboptimal concordance in testing and retesting results of triple-negative breast carcinoma cases among laboratories: one institution experience

Cancer Cell International, 2019
Background Triple-negative breast carcinoma (TNBC) patients do not benefit from hormone- or human epidermal growth factor receptor 2- (HER2-) targeted therapies. Accurate testing is pivotal for these patients. Methods TNBC cases that were retested at our
Jose De Jesus, Marilin Rosa
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source