Results 31 to 40 of about 102,329 (241)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

3D Printing for Space Habitats: Requirements, Challenges, and Recent Advances

Aerospace, 2023
Heavily resource-reliant transportation and harsh living conditions, where humans cannot survive without a proper habitat, have prevented humans from establishing colonies on the Moon and Mars.
Reza Hedayati, Victoria Stulova
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Size effect characteristics and influences on fatigue behavior of laser powder bed fusion of thin wall GRCop-42 copper alloy

Heliyon
Size effects, influencing a material's strength, elongation, fatigue limit, and longevity, depend on the operative and dominant deformation and failure mechanisms. This study explores the size effects in additive manufactured (AM) GRCop-42 (Cu-4at%Cr-2at%
Gabriel Demeneghi, Paul Gradl, Jason R. Mayeur, Kavan Hazeli   +3 more
doaj   +1 more source

Wound and Skin Healing in Space: The 3D Bioprinting Perspective

Frontiers in Bioengineering and Biotechnology, 2021
Skin wound healing is known to be impaired in space. As skin is the tissue mostly at risk to become injured during manned space missions, there is the need for a better understanding of the biological mechanisms behind the reduced wound healing capacity ...
Nieves Cubo-Mateo, Nieves Cubo-Mateo, Michael Gelinsky   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Analyzing the Implementation of a Digital Twin Manufacturing System: Using a Systems Thinking Approach

Systems, 2022
Digital twin (DT) is a technology that promises great benefits for the manufacturing industry. Nevertheless, DT implementation presents many challenges.
Jonatan H. Loaiza, Robert J. Cloutier
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

3D printing in space: from mechanical structures to living tissues

International Journal of Extreme Manufacturing
3D printing stands at the forefront of transforming space exploration, offering unprecedented on-demand and rapid manufacturing capabilities. It adeptly addresses challenges such as mass reduction, intricate component fabrication, and resource ...
Mao Mao, Zijie Meng, Xinxin Huang, Hui Zhu, Lei Wang, Xiaoyong Tian, Jiankang He, Dichen Li, Bingheng Lu   +8 more
doaj   +1 more source

State space properties of Flexible Manufacturing Cell based on Hierarchical Timed Colored Petri Nets

MATEC Web of Conferences, 2017
The subject of this paper is focused on the state space behavioral structure of a flexible manufacturing cell (FMC) using a hierarchical model based on Colored Timed Petri Nets theory.
Saren Sanjib Kumar, Blaga Florin, Vesselenyi Tiberiu   +2 more
doaj   +1 more source