Results 101 to 110 of about 114,871,075 (252)

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathway

Journal of Pharmaceutical Analysis
Anlotinib has strong antiangiogenic effects and leads to vessel normalization. However, the “window period” characteristic in regulating vessel normalization by anlotinib cannot fully explain the long-term survival benefits achieved through combining it ...
Xuedan Han, Jialei Liu, Yidong Zhang, Eric Tse, Qiyi Yu, Yu Lu, Yi Ma, Lufeng Zheng   +7 more
doaj   +1 more source

Business Retention and Expansion Aggregated Data

These data were collected in individual business surveys over the past 25 years as part of the Extension's Center for Community Vitality Business Retention and Expansion (BRE) program, and have been aggregated to the community level for release.
University of Minnesota Extension Center for Community Vitality, Business Retention and Expansion Program
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

The Effect of Grade Retention on High School Completion [PDF]

Low-achieving students in many school districts are retained in a grade in order to allow them to gain the academic or social skills that teachers believe are necessary to succeed academically. This practice is highly controversial, with many researchers
Brian Jacob, Lars Lefgren
core  

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

In-vessel and depth-resolved semi-quantitative analysis on hydrogen isotopes and wall materials in JET by LIBS operated on a remote handling arm

Nuclear Materials and Energy
The tokamak JET achieved a groundbreaking milestone in nuclear fusion during its final deuterium–tritium experimental campaign (DTE-3) by setting a new world energy record [1].
Rongxing Yi, Rahul Rayaprolu, Jari Likonen, Salvatore Almaviva, Ionut Jepu, Gennady Sergienko, Anna Widdowson, Nick Jones, Sahithya Atikukke, Timo Dittmar, Juuso Karhunen, Pawel Gasior, Marc Sackers, Shweta Soni, Erik Wüst, Jelena Butikova, Wojciech Gromelski, Antti Hakola, Indrek Jõgi, Peeter Paris, Jasper Ristkok, Pavel Veis, Sebastijan Brezinsek   +22 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Assessment of thermal safety margins for the IVR-ERVC strategy of the i-SMR using the CINEMA code

Nuclear Engineering and Technology
In-vessel corium retention with external reactor vessel cooling (IVR-ERVC) is a key severe accident mitigation strategy to prevent lower-head failure and retain fission products inside the reactor vessel. This study assesses the applicability of IVR-ERVC
Dong-Hun Shin, Sang Ho Kim, Donggun Son, Yonadan Choi, Young Hee Kim, Hyoung Suk Yu, Yong Hoon Jeong   +6 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source