Results 21 to 30 of about 110 (48)

Genome bioinformatic analysis of nonsynonymous SNPs [PDF]

open access: yes, 2007
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism ...
Catherine L Worth   +6 more
core   +4 more sources

Efficacy and Safety Outcomes for Originator TNF Inhibitors and Biosimilars in Rheumatoid Arthritis and Psoriasis Trials: A Systematic Literature Review [PDF]

open access: yes, 2018
Objective Regulatory approval of biosimilar versions of originator biotherapeutics requires that new biological products be highly similar to originator products, with no clinically meaningful differences in safety, purity, and potency. In some trials of
Curiale, Cinzia   +5 more
core   +1 more source

Unique classification of parathyroid dysfunction in patients with transfusion dependent thalassemia major using nomogram: A cross sectional study [PDF]

open access: yes, 2019
Introduction: Hypoparathyroidism is a rare complication of iron overload in patients with transfusion dependent β thalassemia major (β-TM). We aim to determine the prevalence of parathyroid dysfunction in patients with β-TM.
Ahmed, Sibtain   +5 more
core   +1 more source

Complex temporal patterns processing by a neural mass model of a cortical column [PDF]

open access: yes, 2019
It is well known that neuronal networks are capable of transmitting complex spatiotemporal information in the form of precise sequences of neuronal discharges characterized by recurrent patterns.
Malagarriga, Daniel   +2 more
core   +2 more sources

Using large eddy simulations to reveal the size, strength, and phase of updraft and downdraft cores of an Arctic mixed‐phase stratocumulus cloud [PDF]

open access: yes, 2017
Three‐dimensional large eddy simulations (LES) are used to analyze a springtime Arctic mixed‐phase stratocumulus observed on 26 April 2008 during the Indirect and Semi‐Direct Aerosol Campaign.
  +52 more
core   +1 more source

Accounting for ocean connectivity and hydroclimate in fish recruitment fluctuations within transboundary metapopulations [PDF]

open access: yes, 2019
International audienceMarine resources stewardships are progressively becoming more receptive to an effective incorporation of both ecosystem and environmental complexities into the analytical frameworks of fisheries assessment.
Alemany, Francisco   +10 more
core   +4 more sources

Ensino de Matemática com a Robótica: Uma Proposta de Recurso Didático [PDF]

open access: yes, 2023
Este artigo é fruto de uma pesquisa já concluída, em que se investigou como a robótica pode ser utilizada como recurso didático aliado a metodologia de resolução de problemas e a ideia de gamificação para o ensino e a aprendizagem de matemática.
Lima, Carlos Alberto dos Santos   +1 more
core   +1 more source

Psoriatic arthritis: epidemiological and clinical aspects in a cohort of 1.306 italian patients [PDF]

open access: yes, 2005
Because there is the impression that psoriatic arthritis is a composite disorder with mild forms close to more severe and aggressive ones, we conducted a multicenter study with the aim of characterizing disease expression in a large cohort of Italian ...
Cervini C   +4 more
core   +1 more source

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