Results 121 to 130 of about 700,727 (353)

Thalamus enables active dendritic coupling of inputs arriving at different cortical layers

Nature Communications
Dendritic calcium action potentials (APs) enable the main output neurons of the cerebral cortex – pyramidal tract neurons (PTs) – to associate inputs that arrive at different cortical layers.
Arco Bast, Jason M. Guest, Rieke Fruengel, Rajeevan T. Narayanan, Christiaan P. J. de Kock, Marcel Oberlaender   +5 more
doaj   +1 more source

Biología in silico

, 2023
La biología <i> in silico </i> hace referencia a toda aquella investigación que se realiza a través de un equipo de cómputo, en un entorno virtual, comúnmente a través de la Web, se conoce también como e-biología o biología digital, es practicada por distintas comunidades que trabajan en equipos multidisciplinarios que se centran en los ...
openaire   +1 more source

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo

, 2022
Suzan Demir Pektaş, Murat Kara, Gürsoy Doğan, Mehmet Bilgehan Pektaş, Mehmet Cengiz Baloğlu, Gökhan Sadı   +5 more
openalex   +1 more source

Artificial Intelligence‐Assisted Workflow for Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling

Advanced Materials, EarlyView.
AI‐Assisted Workflow for (Scanning) Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling. Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of ...
Marc Botifoll, Ivan Pinto‐Huguet, Enzo Rotunno, Thomas Galvani, Catalina Coll, Payam Habibzadeh Kavkani, Maria Chiara Spadaro, Yann‐Michel Niquet, Martin Børstad Eriksen, Sara Martí‐Sánchez, Georgios Katsaros, Giordano Scappucci, Peter Krogstrup, Giovanni Isella, Andreu Cabot, Gonzalo Merino, Pablo Ordejón, Stephan Roche, Vincenzo Grillo, Jordi Arbiol   +19 more
wiley   +1 more source

The effect of non-local coupling of fibroblasts on pacing dynamics in a 2D tissue: a simulation study

Scientific Reports
Although myocytes in healthy hearts are usually coupled to nearest neighbours via gap junctions, under conditions such as fibrosis, in scar tissue, or across ablation lines, myocytes can uncouple from their neighbours.
S. Sridhar, Richard H. Clayton
doaj   +1 more source

Investigation of Neuroprotective Potential of Anti-Diabetic Agents in Ischemic Brain Proteomics Through In-Silico Molecular Simulation Studies

, 2021
Vishal Chavda, Vimal Patel, Snehal Patel, M Yazar, P zbek, N Agarwal, V Chetry, K Poluri, V Sulimov, D Kutov, A Taschilova, I Ilin, E Tyrtyshnikov, A Sulimov, A Naqvi, T Mohammad, G Hasan, M Hassan, E Air, B Kissela, F Lyu, D Wu, C Wei, A Wu, R Chen, B Ovbiagele, W Feng, P Li, W Quan, D Lu, Y Wang, H Zhang, S Liu, R Jiang, Y Zhou, T Van Sloten, S Sedaghat, M Carnethon, L Launer, C Stehouwer, J Murphy, N Ho, M Sommers, I Lucki, L Westphal, U Held, S Engelter, S Wegener, C Gohil, M Noolvi, O Trott, A Olson, Z Wang, N He, Z Guo, C Niu, T Song, Y Guo, K Cao, A Wang, J Zhu, X Zhang, Z Zhang, S Singh, A Upadhyay, M Reddy, V Patel, J Shah, A Gupta, W Worawalai, P Sompornpisut, S Wacharasindhu, P Phuwapraisirisan, P Kalhotra, V Chittepu, G Osorio-Revilla, T Gallardo-Velzquez, S Kulkarni, P Gupta, A Pallavi, K Boatright, G Salvesen, L Yao, P Swartz, P Hamilton, A Clark, H Park, M Renatus, H Stennicke, F Scott, R Liddington, G Salvesen, M Akbari, V Hassan-Zadeh, V Veverka, T Baker, N Redpath, B Carrington, F Muskett, R Taylor   +99 more
openalex   +1 more source

In Silico Roots

Trends in Plant Science, 2019
Computational models are invaluable tools for understanding the hormonal and genetic control of root development. Thus far, models have focused on the crucial roles that auxin transport and metabolism play in determining the auxin signaling gradient that controls the root meristem.
Rutten, Jacob Pieter, ten Tusscher, Kirsten   +1 more
openaire   +1 more source

Beyond Presumptions: Toward Mechanistic Clarity in Metal‐Free Carbon Catalysts for Electrochemical H2O2 Production via Data Science

Advanced Materials, EarlyView.
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu, Hsi‐wen Wu, Xiao Wang, Jie Zhang   +3 more
wiley   +1 more source