Results 251 to 260 of about 700,727 (353)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

A Generalized Framework for Data‐Efficient and Extrapolative Materials Discovery for Gas Separation

Advanced Intelligent Discovery, EarlyView.
This study introduces an iterative supervised machine learning framework for metal‐organic framework (MOF) discovery. The approach identifies over 97% of the best performing candidates while using less than 10% of available data. It generalizes across diverse MOF databases and gas separation scenarios.
Varad Daoo, Jayant K. Singh
wiley   +1 more source

Alternative methods for pharmacological research on the action mechanisms of natural products used in the treatment of type 2 diabetes: a systematic review. [PDF]

Front Pharmacol
Espinoza-Hernández FA, Martínez-Medina S, Mata-Torres G, Cabello-Hernández CA, Andrade-Cetto A.   +4 more
europepmc   +1 more source

A Computational Approach for Biomimetic Design of Liver‐On‐A‐Chip

Advanced Intelligent Discovery, EarlyView.
A biomimetic liver‐on‐a‐chip with antiparallel perfusion was designed using COMSOL‐guided simulation to replicate hepatic acinus transport. Full‐scale modelling revealed diffusion‐dominated, length‐dependent nutrient gradients and low‐shear conditions.
Zhenxu Yang, Qiankun Yin, Qingxin Liu, Zhejun Xu, Ye Zhang, Christopher Vega‐Sánchez, Xiaochen Liu, Daniele Vigolo, Jiao Jiao Li, Ken‐Tye Yong   +9 more
wiley   +1 more source

Pedicle screws close to the cranial endplate cause accelerated adjacent segment degeneration - a clinical cohort study supported by finite element analysis

Brain and Spine
A. Lazary, F. Bereczki, A. Pokorni, M. Turbucz, P. Eltes   +4 more
doaj   +1 more source

Enhancing African horse sickness virus detection: comparing and adapting PCR assays. [PDF]

J Vet Diagn Invest
Penzhorn L, Crafford JE, Guthrie AJ.
europepmc   +1 more source

IN SILICO COMPUTATIONAL SCREENING OF PHYTOCONSTITUENTS OF POLYHERBAL FORMULATION SUKKUMALLI KASHAYAM AGAINST MPRO, SPIKE PROTEIN AND TMPRSS2 PROTEASE INHIBITOR FOR SARS-COV-2

openalex   +1 more source

Holistic approaches to pre-clinical TKR analysis: computationally-enriched experimental testing

, 2009
Dressler, Matthew R., Render, Todd, Strickland, Michael A., Taylor, Mark   +3 more
core  

Accelerating Biosensor Discovery: A Computationally‐Driven Pipeline for Microplastics Monitoring

Advanced Intelligent Discovery, EarlyView.
A computationally guided pipeline unites molecular simulation, synthetic biology, electrochemical engineering, and machine learning to accelerate biosensor discovery. A Bacillus anthracis carbohydrate‐binding module is used to develop a high‐performance micro‐ and nanoplastics sensor with greatly reduced error and variability.
Gabriel X. Pereira, Marcos de C. Leite, Pedro H. M. Zanineli, Juliana N. Y. Costa, Débora M. Cunha, Sophia P. Serra, Pedro H. Sophia, Flávio M. Shimizu, Yasmin W. Moura, Célio C. Oliveira, Gabriel R. Schleder, Gabriela F. Persinoti, Leandro Merces, Renato S. Lima   +13 more
wiley   +1 more source