Results 81 to 90 of about 114,730,533 (182)

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway

Materials Today Bio
Critical bone defect with soft tissue fenestration poses a significant therapeutic challenge without the premise of barrier periosteum in situ for the relatively independent repair spaces of soft tissue and bone. Inspired by the regenerative functions of
Zhengchuan Zhang, Jiaqi Shen, Ruogu Xu, Yang Yang, Xiaolin Yu, Dongsheng Yu, Feilong Deng   +6 more
doaj   +1 more source

In situ laser fenestration technique : bench-testing of aortic endograft to guide clinical practice

Purpose: In situ laser fenestration (ISLF) is a recently introduced technology that offers the potential to perform total endovascular treatment of aortic arch and thoracoabdominal aortic pathologies in the acute setting.
Wanhainen, Anders, Grima, Matthew Joe, Grima, Matthew Joe,, Wanhainen, Anders,, Lindström, David,, Lindström, David   +5 more
core   +1 more source

Burgemeester van Suchtelenstraat Ex-Situ Archeologierapport 5

, 2022
Op 19 februari 2019 heeft Ex-Situ Archeologie een proefsleuvenonderzoek uitgevoerd op het perceel Burgermeester van Suchtelenstraat in de gemeente Beuningen.
Ex-Situ arch. advies en projectbureau
core   +1 more source

Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics

Macromolecular Bioscience, Volume 26, Issue 7, July 2026.
Nucleic acid therapeutics have been investigated to expand their applications to renal genetic disorders. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys.
Jun Hyuk Lee, Junku Han, Sehwan Park, Hyejung Mok   +3 more
wiley   +1 more source

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT This study describes the implementation of a mechanistic subcutaneous (SC) injection model for the Open Systems Pharmacology platform. As the SC route of administration is gaining increased popularity, there is a growing need for tools to predict, analyze, and understand the SC absorption process and the mechanisms involved.
Moriah Pellowe, Ilse Dubbelboer, Erik Sjögren   +2 more
wiley   +1 more source

No Sex Differences in the Amount of Type IV Collagen in Wistar Rats Regardless of Sampling Strategy

APMIS, Volume 134, Issue 7, July 2026.
ABSTRACT Serum collagen IV (Col IV) is an important marker for staging liver fibrosis, but histological baselines in healthy tissue are often lacking or biased. This study applied unbiased stereological sampling to quantify liver Col IV in healthy adult Wistar rats and assess sex differences.
Patrik Mik, Katsiaryna Barannikava, Polina Surkova, Richard Pálek, Jáchym Rosendorf, Štěpánka Jansová, Václav Liška, Zbyněk Tonar   +7 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

In-situ needle fenestration technique for preserving the left subclavian artery in emergent TEVAR

Angiologia e Cirurgia Vascular
BACKGROUND: Open aortic repair is the gold standard in the treatment of diseases involving the aortic arch, but high-risk patients are often not suitable candidates for surgical repair.
João Peixoto, Marco Virgílio Usai, Martin Austernmann   +2 more
doaj   +1 more source

In Situ Stent-Graft Fenestration to Preserve the Left Subclavian Artery

Journal of Endovascular Therapy, 2004
To report our first clinical application of a new technique for in situ fenestration of a thoracic stent-graft.After completing a series of in vitro and in vivo experiments, in situ stent-graft fenestration was employed during endograft repair of a saccular thoracic aortic aneurysm in a 77-year-old woman.
Richard G, McWilliams, Micheal, Murphy, David, Hartley, Michael M D, Lawrence-Brown, Peter L, Harris   +4 more
openaire   +2 more sources