Results 231 to 240 of about 22,161 (294)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Rapid Diagnostic Testing in Bloodstream Infections: A Retrospective Clinical and Economic Evaluation from a University Hospital in Bulgaria. [PDF]

Microorganisms
Raycheva R, Lengerova G, Petrov M, Kantardjiev T.   +3 more
europepmc   +1 more source

Comparative Oligo‐FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years

Advanced Science, EarlyView.
Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He, Hainan Zhao, Xiaoxue Zeng, Zujun Yang, Wenting Li, Guoyan Zhang, Guangrong Li, Jian He, Bin Guan, Jiming Jiang   +9 more
wiley   +1 more source

Rapid evolution in necromass use under resource limitation reduces persistence in producer-decomposer microbial biospheres. [PDF]

Commun Biol
Jiang S, Halbleib A, Antonovics J, Remus-Emsermann M, Rillig MC, Mansour I.   +5 more
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Conservation and Sustainable Development of Rice Landraces for Enhancing Resilience to Climate Change, with a Case Study of 'Pantiange Heigu' in China. [PDF]

Life (Basel)
Kou S, Ci Z, Liu W, Wu Z, Peng H, Yuan P, Jiang C, Li H, Mansour E, Huang P.   +9 more
europepmc   +1 more source

Promoting utilization of donors after circulatory death in lung transplantation. [PDF]

JHLT Open
Gouchoe DA, Cardenas A, Marklin GF, Bush E, Whitson BA, Hoffman JRH, Stewart D, Axelrod DA, Siddique A.   +8 more
europepmc   +1 more source

Surface engineering and local electron structure modulation to accelerate electroreduction of low-concentration nitrate. [PDF]

Chem Sci
Gao Z, Liang J, Sun M, Yin X, Ling H, Wang J, Wei K, Li K, Han W.   +8 more
europepmc   +1 more source

Searching for extraterrestrial life advances terrestrial sustainability. [PDF]

Nat Commun
Howells AEG, Fontana CG, Elkassas S, Caro TA, Kashyap S.   +4 more
europepmc   +1 more source

Metabolic plasticity and therapeutic opportunity in cancer. [PDF]

Oncogenesis
Shen S.
europepmc   +1 more source