Results 31 to 40 of about 217,740 (263)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Development and application of in-situ testing system for anisotropic deformation in loess pores

Yantu gongcheng xuebao
In order to solve the problems of ignoring anisotropy of soils and single loading direction in the traditional in-situ soil deformation testing, a design concept of anisotropic deformation in-situ testing system for loess is proposed.
YAN Changgen 1, 2 , WANG Yifan 1, LAN Hengxing 3, 4, YANG Mingyu 1, DONG Zhonghong 5, LEI Wenbin 5, ZHANG Hongbing 5, LI Sen 5
doaj   +1 more source

Clinching in in-situ CT—A numerical study on suitable tool materials

Journal of Advanced Joining Processes, 2020
In lightweight design, clinching is a cost efficient joining method, especially for different joined materials and thicknesses. The quality of such a joint is usually evaluated by ex-situ destructive testing methods.
Daniel Köhler, Robert Kupfer, Maik Gude
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Investigation and Analysis of the Influence of Depth and Moisture Content on the Relationship Between Subgrade California Bearing Ratio Tests and Cone Penetration Tests for Pavement Design

Buildings
Evaluation of soil properties in highway design is an important but time-consuming task that does not always provide the necessary information to detect issues associated with changes in soil properties along the road project.
Ricardo Moffat, Felipe Faundez, Felipe A. Villalobos   +2 more
doaj   +1 more source

The hydrogen embrittlement sensitivity of duplex stainless steel with different phase fractions evaluated by in-situ mechanical testing

Fracture and Structural Integrity, 2020
The influence of the austenite (γ) phase fraction on the hydrogen embrittlement of duplex stainless steel is investigated. Heat treatments are performed to create two duplex stainless steel specimens, containing 50% and 44% of austenite, respectively ...
Margo Cauwels, Lisa Claeys, Tom Depover, Kim Verbeken   +3 more
doaj   +1 more source

Design, Analysis and Experiment of the Fiber Push-Out Device Based on Piezoelectric Actuator

Micromachines, 2021
In this study, a fiber push-out device based on a piezoelectric actuator was designed, analyzed and tested, and its experimental environment was designed. The piezoelectric actuator includes a flexible beam.
Mengxin Sun, Yong Feng, Jiangtao Xu, Xiaoyu Wang, Haojie Zhou   +4 more
doaj   +1 more source

In Situ Field Testing of Processes [PDF]

, 2001
The purpose of this Analysis/Model Report (AMR) is to update and document the data and subsequent analyses from ambient field-testing activities performed in underground drifts of the Yucca Mountain Site Characterization Project (YMP). This revision updates data and analyses presented in the initial issue of this AMR.
openaire   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Investigating the Morphology and Mechanics of Biogenic Hierarchical Materials at and below Micrometer Scale

Nanomaterials, 2022
Investigating and understanding the intrinsic material properties of biogenic materials, which have evolved over millions of years into admirable structures with difficult to mimic hierarchical levels, holds the potential of replacing trial-and-error ...
Mohammad Soleimani, Sten J. J. van den Broek, Rick R. M. Joosten, Laura S. van Hazendonk, Sai P. Maddala, Lambert C. A. van Breemen, Rolf A. T. M. van Benthem, Heiner Friedrich   +7 more
doaj   +1 more source