Results 101 to 110 of about 517,738 (337)

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization

Neurobiology of Disease, 2016
Correct positioning and differentiation of neurons during brain development is a key precondition for proper function. Focal cortical dysplasias (FCDs) are increasingly recognized as causes of therapy refractory epilepsies.
Alexander Grote, Barbara K. Robens, Ingmar Blümcke, Albert J. Becker, Susanne Schoch, Eva Gembé   +5 more
doaj   +1 more source

Multipotency of mouse trophoblast stem cells

Stem Cell Research & Therapy, 2020
Background In a number of disease processes, the body is unable to repair injured tissue, promoting the need to develop strategies for tissue repair and regeneration, including the use of cellular therapeutics.
Minmin Hou, Junwen Han, Gu Li, Min-Young Kwon, Jiani Jiang, Sirisha Emani, Elizabeth S. Taglauer, Jin-Ah Park, Eun-Bee Choi, Munender Vodnala, Yick W. Fong, Sitaram M. Emani, Ivan O. Rosas, Mark A. Perrella, Xiaoli Liu   +14 more
doaj   +1 more source

The influence of frozen-thawed and fresh embryo transfer on utero-placental (vascular) development: the Rotterdam Periconception cohort [PDF]

, 2021
Linette van Duijn, Melek Rousian, Igna F. Reijnders, Sten P. Willemsen, Esther B. Baart, Joop S.E. Laven, Régine P.M. Steegers‐Theunissen   +6 more
openalex   +1 more source

High-speed, high-frequency ultrasound, \u3ci\u3ein utero\u3c/i\u3e vector-flow imaging of mouse embryos [PDF]

, 2019
Real-time imaging of the embryonic murine cardiovascular system is challenging due to the small size of the mouse embryo and rapid heart rate. High-frequency, linear-array ultrasound systems designed for small-animal imaging provide high-frame-rate and ...
Aristizabal, Orlando, Ketterling, Jeffrey A., Phoon, Colin K. L., Silverman, Ronald H., Turnbull, Daniel H., Yiu, Billy Y. S., Yu, Alfred C. H.   +6 more
core   +1 more source

White and grey matter development in utero assessed using motion-corrected diffusion tensor imaging and its comparison to ex utero measures

Magnetic Resonance Materials in Physics, Biology and Medicine, 2019
ObjectiveFetal brain diffusion tensor imaging (DTI) offers quantitative analysis of the developing brain. The objective was to 1) quantify DTI measures across gestation in a cohort of fetuses without brain abnormalities using full retrospective ...
Georgia Lockwood Estrin, Zhiqing Wu, M. Deprez, Á. Bertelsen, M. Rutherford, S. Counsell, J. Hajnal   +6 more
semanticscholar   +1 more source

Delivery strategies of messenger RNA therapeutics for brain disorders

Bulletin of the Korean Chemical Society, EarlyView.
Thus, mRNA therapeutics offer a powerful new avenue for the treatment of brain diseases. This review examines strategies to bypass biological barriers, particularly the blood–brain barrier, and explores emerging delivery systems, such as direct intracerebral injection, intracerebroventricular injection, systemic delivery (including intravenous ...
Kounghwa Youn, Sunmin Oh, Hyunchae Gil, Yongseok Choi, Gyochang Keum, Eun‐Kyoung Bang   +5 more
wiley   +1 more source

Fréquence et facteurs de risque maternels de la mort fètale in utero à Kamina, République Démocratique du Congo

The Pan African Medical Journal, 2016
INTRODUCTION: la mort fètale in utero constitue un problème fréquent dans la pratique obstétricale. Les objectifs de cette étude étaient de déterminer la fréquence et d'identifier les facteurs de risque de la mort fètale in utero à l'Hôpital Général de ...
Ignace Bwana Kangulu, Albert Mwembo Tambwe AèNkoy, John Ngoy Lumbule, Elie Kilolo Ngoy Umba, Michel Kabamba Nzaji, Prosper Kalenga Muenze Kayamba   +5 more
doaj   +1 more source

NanoTIO₂ (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice

Particle and Fibre Toxicology, 2012
Background Particulate air pollution has been linked to an increased risk of cardiovascular disease and cancer. Animal studies have shown that inhalation of air particulates induces mutations in the male germline.
Boisen Anne Mette, Shipley Thomas, Jackson Petra, Hougaard Karin, Wallin Håkan, Yauk Carole L, Vogel Ulla   +6 more
doaj   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

Developmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez, Niusha Banoukh, Fiona Mensching, Robert V. Skibbens, M. Kathryn Iovine   +4 more
wiley   +1 more source

Prenatal origin of childhood AML occurs less frequently than in childhood ALL [PDF]

, 2006
Background While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive.
AM Ford, AT Maia, AT Maia, AT Maia, Bjoern Schneider, C Meyer, Claus Meyer, CM McHale, CM McHale, Felix Votava, GS Makowski, H Kempski, H Kiyoi, J Zuna, Jan Stary, Jan Trka, Jan Zuna, JL Wiemels, JL Wiemels, JL Wiemels, JL Wiemels, Jozef Madzo, JW Taub, K Fasching, Katerina Muzikova, KB Gale, KE Richkind, LK Jones, LL Hjalgrim, LY Shih, MD Megonigal, MF Greaves, MJ Pongers-Willemse, N Goulden, PD Kottaridis, Rolf Marschalek, S Meshinchi, SA Miller, SC Raimondi, T Szczepanski, T Yagi, Tatiana Burjanivova   +41 more
core   +3 more sources