Results 21 to 30 of about 517,738 (337)

Dual in Utero Electroporation in Mice to Manipulate Two Specific Neuronal Populations in the Developing Cortex

Frontiers in Bioengineering and Biotechnology, 2022
Precise regulation of gene expression during development in cortical neurons is essential for the establishment and maintenance of neuronal connectivity and higher-order cognition.
Longbo Zhang, S. A. Getz, A. Bordey
semanticscholar   +1 more source

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease

Nature Communications, 2021
In utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting multiple organs, often leading to early ...
S. Bose, Brandon M. White, Meghana V. Kashyap, A. Dave, F. D. De Bie, Haiying Li, Kshitiz Singh, P. Menon, Tiankun Wang, Shiva Teerdhala, Vishal B. Swaminathan, Heather A. Hartman, S. Jayachandran, P. Chandrasekaran, K. Musunuru, Rajan Jain, D. Frank, P. Zoltick, W. Peranteau   +18 more
semanticscholar   +1 more source

A quantitative cholinergic and catecholaminergic 3D Atlas of the developing mouse brain

NeuroImage, 2022
The complex organization of brain regions during development requires a three-dimensional approach to facilitate the visualization and quantification of dynamic changes taking place throughout this important period.
B. Riffault, R. Cloarec, H. Rabiei, M. Begnis, D.C. Ferrari, Yehezkel Ben-Ari   +5 more
doaj   +1 more source

Late-Gestation in utero Heat Stress Limits Dairy Heifer Early-Life Growth and Organ Development

Frontiers in Animal Science, 2021
Dairy calves exposed to late-gestation heat stress weigh less, have impaired immunity, produce less milk across multiple lactations, and have reduced productive life.
B. Dado-Senn, S. Field, B. D. Davidson, L. Casarotto, M. G. Marrero, V. Ouellet, F. Cunha, Melissa A. Sacher, Cash L. Rice, F. Maunsell, G. Dahl, J. Laporta   +11 more
semanticscholar   +1 more source

Distinct Synaptic Vesicle Proteomic Signatures Associated with Pre- and Post-Natal Oxycodone-Exposure

Cells, 2022
The current opioid crisis, which has ravaged all segments of society, continues to pose a rising public health concern. Importantly, dependency on prescription opioids such as oxycodone (oxy) during and after pregnancy can significantly impact the ...
Katherine E. Odegaard, Gabriel Gallegos, Sneh Koul, Victoria L. Schaal, Neetha N. Vellichirammal, Chittibabu Guda, Andrea P. Dutoit, Steven J. Lisco, Sowmya V. Yelamanchili, Gurudutt Pendyala   +9 more
doaj   +1 more source

Viable bacterial colonization is highly limited in the human intestine in utero

Nature Network Boston, 2020
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet whether viable microbes exist in utero and interact with the intestinal immune system is unknown.
E. Rackaityte, J. Halkias, E. Fukui, V. Mendoza, C. Hayzelden, E. Crawford, K. Fujimura, T. Burt, S. Lynch   +8 more
semanticscholar   +1 more source

In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood

Frontiers in Endocrinology, 2021
Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance. Metformin is also used in the treatment of pregnancy disorders such as gestational diabetes.
Mélanie C. Faure, Rita Khoueiry, Jusal Quanico, H. Acloque, Marie-Justine Guerquin, M. Bertoldo, C. Chevaleyre, C. Ramé, I. Fournier, M. Salzet, J. Dupont, P. Froment   +11 more
semanticscholar   +1 more source

Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models

Frontiers in Physiology, 2021
Matrix metalloproteinase-12 (Mmp12) is upregulated by cigarette smoke (CS) and plays a critical role in extracellular matrix remodeling, a key mechanism involved in physiological repair processes, and in the pathogenesis of emphysema, asthma, and lung ...
A. Noël, Z. Perveen, R. Xiao, Harriet L. Hammond, Viviana Le Donne, Kelsey P. Legendre, M. Gartia, Sushant P Sahu, D. Paulsen, A. Penn   +9 more
semanticscholar   +1 more source

Quantification of Mouse Embryonic Eye Development with Optical Coherence Tomography In Utero

Journal of Biomedical Photonics & Engineering, 2015
Mouse models are commonly used as research tools to understand regulatory pathways affected by human diseases and disorders. Live imaging tools for visualization of mouse embryonic ocular tissues would be beneficial in research associated with ...
Narendran Sudheendran, Maleeha Mashiatulla, Raksha Raghunathan, Saba H. Syed, Mary E. Dickinson, Irina V. Larina, Kirill V. Larin   +6 more
doaj   +1 more source

Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model [PDF]

, 2006
Objective: To evaluate maxillary growth following in utero repair of surgically created cleft lip and alveolar (CLA)-like defects by means of three-dimensional (3D) computer tomographic (CT) cephalometric analysis in the mid-gestational sheep model ...
Adzick NS, Adzick NS, Bardach J, Canady JW, Canady JW, Christina Jannowitz, Dodson TB, Edgar Biemer, Engdahl E, Evans ML, Hallock GG, Hallock GG, Hans-Florian Zeilhofer, Harrison MR, Hedrick MH, Huhn EA, Julia Henke, Kaban LB, Laszlo Kovacs, Levine JP, Longaker MT, Longaker MT, Longaker MT, Longaker MT, Longaker MT, Molsted K, Moschos A. Papadopoulos, Nikolaos A. Papadopulos, Papadopoulos MA, Papadopoulos MA, Papadopulos NA, Papadopulos NA, Papadopulos NA, Papadopulos NA, Papadopulos NA, Peter Boettcher, Popesko P, Rudolf Stolla, Smith R, Stelnicki EJ, Stelnicki EJ, Stelnicki EJ, Stern M, Stern M, Sullivan WG, Waite DE   +45 more
core   +1 more source