Results 41 to 50 of about 517,738 (337)

Pesticide exposure and its effects on intrauterine and postnatal development

Perinatología y Reproducción Humana, 2023
Background: The period between conception and the first two postnatal years is critical and marks the individual, largely determining their health and disease patterns.
Ana L. Calderón-Garcidueñas, Ma. del Carmen Martínez-Valenzuela, Stefan M. Waliszewski-Kubiak   +2 more
doaj   +1 more source

Beyond Passive Immunity: Is There Priming of the Fetal Immune System Following Vaccination in Pregnancy and What Are the Potential Clinical Implications?

Frontiers in Immunology, 2018
Infection is responsible for over half a million neonatal deaths worldwide every year, and vaccination in pregnancy is becoming increasingly recognized as an important strategy for the protection of young infants.
Christopher R. Wilcox, Christine E. Jones   +1 more
doaj   +1 more source

Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study [PDF]

, 2014
OBJECTIVES: Transgenerational effects of different environmental exposures are of major interest, with rodent experiments focusing on epigenetic mechanisms. Previously, we have shown that if the study mother is a non-smoker, there is increased mean birth
Golding, Jean, Gregory, Steven, Miller, Laura L, Northstone, Kate, Pembrey, Marcus   +4 more
core   +1 more source

The Greater Proportion of Born-Light Progeny from Sows Mated in Summer Contributes to Increased Carcass Fatness Observed in Spring

Animals, 2020
The backfat of pig carcasses is greater in spring than summer in Australia. The unexplained seasonal variation in carcass backfat creates complications for pig producers in supplying consistent lean carcasses. As a novel explanation, we hypothesised that
Fan Liu, Erin M. Ford, Rebecca S. Morrison, Chris J. Brewster, David J. Henman, Robert J. Smits, Weicheng Zhao, Jeremy J. Cottrell, Brian J. Leury, Frank R. Dunshea, Alan W. Bell   +10 more
doaj   +1 more source

Human neural stem cell transplantation in ALS: initial results from a phase I trial [PDF]

, 2015
We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and ...
Bernardini, Laura, Bersano, Enrica, Binda, Elena, Boulis, Nicholas M, Cantello, Roberto, Carletti, Sandro, Carriero, Alessandro, Cerino, Annalisa, Cima, Valentina, Cisari, Carlo, Domenico, Frondizi, Ferrari, Daniela, Gaiani, Alessandra, Gelati, Maurizio, Giorgi, Cesare, Glass, Jonathan, Maglione, Annamaria, Masiero, Stefano, Massara, Maurilio, Mazzini, Letizia, Muzi, Gianmarco, Nasuelli, Nicola, Novelli, Antonio, Petruzzelli, Francesco, Prandi, Paolo, Profico, Daniela Celeste, Projetti Pensi, Massimo, Querin, Giorgia, Ricciolini, Claudia, Rota Nodari, Laura, Sarnelli, Maria Francesca, Servo, Serena, Sgaravizzi, Giada, Soraru', Gianni, Spera, Cristina, Stecco, Alessandro, Torres, Barbara, Trombetta, Domenico, Vescovi, Angelo L., Visioli, Alberto, Zalfa, Cristina   +40 more
core   +2 more sources

Epigenetics and In Utero Acquired Predisposition to Metabolic Disease

Frontiers in Genetics, 2020
Epidemiological evidence has shown an association between prenatal malnutrition and a higher risk of developing metabolic disease in adult life. An inadequate intrauterine milieu affects both growth and development, leading to a permanent programming of ...
A. Deodati, E. Inzaghi, S. Cianfarani
semanticscholar   +1 more source

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Environment International, 2022
Background: The detrimental health effects associated with the receipt of moderate (0.1–1 Gy) and high (>1 Gy) acute doses of sparsely ionising radiation are well established from human epidemiological studies.
Mark P. Little, Richard Wakeford, Simon D. Bouffler, Kossi Abalo, Michael Hauptmann, Nobuyuki Hamada, Gerald M. Kendall   +6 more
doaj   +1 more source

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Environmental Health, 2017
Background Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist during fetal development.
Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas, David J. Robbins   +7 more
doaj   +1 more source

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

Microbiome, 2017
After more than a century of active research, the notion that the human fetal environment is sterile and that the neonate’s microbiome is acquired during and after birth was an accepted dogma.
M. Perez-Muñoz, M. Arrieta, A. Ramer-Tait, J. Walter   +3 more
semanticscholar   +1 more source

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. [PDF]

, 2018
CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII and replace it with mutated forms in single neurons, we have rigorously ...
Asensio, Cedric S, Bender, Kevin J, Díaz-Alonso, Javier, Iafrati, Jillian, Incontro, Salvatore, Nicoll, Roger A, Roche, Katherine W, Sohal, Vikaas S, Vieira, Marta   +8 more
core   +2 more sources