Results 51 to 60 of about 261,136 (339)

Prenatal exposures and exposomics of asthma

AIMS Environmental Science, 2015
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental ...
Hyunok Choi, Mark T. McAuley, David A. Lawrence   +2 more
doaj   +1 more source

Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis. [PDF]

, 2020
Over the last century, the alarming surge in allergy and autoimmune disease has led to the hypothesis that decreasing exposure to microbes, which has accompanied industrialization and modern life in the Western world, has fundamentally altered the immune
Apostol, April C, Beaudin, Anna E, Jensen, Kirk DC   +2 more
core  

Human neural stem cell transplantation in ALS: initial results from a phase I trial [PDF]

, 2015
We report the initial results from a phase I clinical trial for ALS. We transplanted GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the anterior horns of the spinal cord to test for the safety of both cells and ...
Bernardini, Laura, Bersano, Enrica, Binda, Elena, Boulis, Nicholas M, Cantello, Roberto, Carletti, Sandro, Carriero, Alessandro, Cerino, Annalisa, Cima, Valentina, Cisari, Carlo, Domenico, Frondizi, Ferrari, Daniela, Gaiani, Alessandra, Gelati, Maurizio, Giorgi, Cesare, Glass, Jonathan, Maglione, Annamaria, Masiero, Stefano, Massara, Maurilio, Mazzini, Letizia, Muzi, Gianmarco, Nasuelli, Nicola, Novelli, Antonio, Petruzzelli, Francesco, Prandi, Paolo, Profico, Daniela Celeste, Projetti Pensi, Massimo, Querin, Giorgia, Ricciolini, Claudia, Rota Nodari, Laura, Sarnelli, Maria Francesca, Servo, Serena, Sgaravizzi, Giada, Soraru', Gianni, Spera, Cristina, Stecco, Alessandro, Torres, Barbara, Trombetta, Domenico, Vescovi, Angelo L., Visioli, Alberto, Zalfa, Cristina   +40 more
core   +2 more sources

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Functional brain connectivity in ex utero premature infants compared to in utero fetuses

NeuroImage, 2020
Brain structural changes in premature infants appear before term age. Functional differences between premature infants and healthy fetuses during this period have yet to be explored. Here, we examined brain connectivity using resting state functional MRI
Josepheen De Asis-Cruz, Kushal Kapse, Sudeepta K. Basu, Mariam Said, Dustin Scheinost, Jonathan Murnick, Taeun Chang, Adre du Plessis, Catherine Limperopoulos   +8 more
doaj   +1 more source

In Utero Chlordecone Exposure and Thyroid, Metabolic, and Sex-Steroid Hormones at the Age of Seven Years: A Study From the TIMOUN Mother-Child Cohort in Guadeloupe

Frontiers in Endocrinology, 2021
BackgroundChlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties. This organochlorine insecticide was extensively used in the French West Indies from 1973 to 1993 to control the banana root borer. Due
Gülen Ayhan, Florence Rouget, Frank Giton, Nathalie Costet, Léah Michineau, Christine Monfort, Jean-Pierre Thomé, Philippe Kadhel, Sylvaine Cordier, Alejandro Oliva, Luc Multigner   +10 more
doaj   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

In Utero Brain Growth Matters for Fetuses With Congenital Heart Disease [PDF]

, 2022
Mike Seed, Catherine Limperopoulos
openalex   +1 more source

Embryos as Patients? Medical Provider Duties in the Age of CRISPR/Cas9 [PDF]

, 2017
The CRISPR/Cas9 genome engineering platform is the first method of gene editing that could potentially be used to treat genetic disorders in human embryos. No past therapies, genetic or otherwise, have been intended or used to treat disorders in existent
Powell, G. Edward, III
core   +1 more source

A Microfiber‐Reinforced Janus Hydrogel E‐Skin With Recyclable Feature for Multimodal Sensing and Gender‐Specific Physiological Monitoring

Advanced Science, EarlyView.
Hydrogel‐based wearable electronics hold great promise for physiological monitoring in privacy‐sensitive regions. In this study, a polyurethane (PU) microfiber‐reinforced gelatin hydrogel e‐skin is developed, boasting multiple advantages such as ultra‐thinness, high toughness, and long‐term skin conformability.
Yarong Ding, Yufeng Li, Shaozhe Tan, Jiachun Sun, Xu Yang, Xuesi Zhang, Zhenhua Lin, Zhenyu Li, Yue Hao, Yannan Liu, Yingchun Li, Jingjing Chang   +11 more
wiley   +1 more source