Results 61 to 70 of about 517,738 (337)

In utero gene editing for monogenic lung disease

Science Translational Medicine, 2019
Prenatal CRISPR gene editing results in efficient pulmonary epithelial cell editing and ameliorates a mouse model of a congenital lung disease. Editing out a lethal lung disease Surfactant, a lipoprotein mixture that reduces lung surface tension, is ...
D. Alapati, W. Zacharias, Heather A. Hartman, A. Rossidis, John Stratigis, Nicholas J. Ahn, Barbara E. Coons, Su Zhou, Hiaying Li, Kshitiz Singh, J. Katzen, Y. Tomer, A. Chadwick, K. Musunuru, M. Beers, E. Morrisey, W. Peranteau   +16 more
semanticscholar   +1 more source

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, EarlyView.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, EarlyView.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source

In Utero Chlordecone Exposure and Thyroid, Metabolic, and Sex-Steroid Hormones at the Age of Seven Years: A Study From the TIMOUN Mother-Child Cohort in Guadeloupe

Frontiers in Endocrinology, 2021
BackgroundChlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties. This organochlorine insecticide was extensively used in the French West Indies from 1973 to 1993 to control the banana root borer. Due
Gülen Ayhan, Florence Rouget, Frank Giton, Nathalie Costet, Léah Michineau, Christine Monfort, Jean-Pierre Thomé, Philippe Kadhel, Sylvaine Cordier, Alejandro Oliva, Luc Multigner   +10 more
doaj   +1 more source

Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. [PDF]

, 2014
Polycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes.
Abbott, David H, Dumesic, Daniel A, Grogan, Tristan, Nicol, Lindsey E, O'Brien, Timothy D, Tarantal, Alice F   +5 more
core   +3 more sources

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis

Science Translational Medicine, 2019
In utero and early postnatal functional rescue of cystic fibrosis transmembrane conductance regulator improves survival in cystic fibrosis ferrets. Tackling cystic fibrosis in the womb Cystic fibrosis (CF) is a multiorgan disease caused by mutations in ...
Xingshen Sun, Y. Yi, Ziying Yan, B. H. Rosen, B. Liang, M. Winter, T. Evans, P. Rotti, Yu Yang, Jaimie S. Gray, Soo‐Yeun Park, Weihong Zhou, Yulong Zhang, S. Moll, Lisa Woody, Dao Tran, Licong Jiang, A. Vonk, J. Beekman, P. Negulescu, F. van Goor, D. Fiorino, K. Gibson-Corley, J. Engelhardt   +23 more
semanticscholar   +1 more source

In Utero Diffusion MRI: Challenges, Advances, and Applications. [PDF]

Topics in Magnetic Resonance Imaging (TMRI), 2019
In utero diffusion magnetic resonance imaging (MRI) provides unique opportunities to noninvasively study the microstructure of tissue during fetal development.
D. Christiaens, Paddy J. Slator, L. Cordero-Grande, A. Price, M. Deprez, D. Alexander, M. Rutherford, J. Hajnal, J. Hutter   +8 more
semanticscholar   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Predominance of Cephalic Presentation at Birth: An Oxygen Delivery-Based Concept

Journal of Obstetric Anaesthesia and Critical Care
Background: Fetuses closer to term present predominantly as cephalic, and by the time of delivery 96-97% of them are born headfirst. To date, no coherent hypothesis has been put forth to explain the phenomenon.
Hsui Yang Wong, Yoo Kuen Chan
doaj   +1 more source

In utero CRISPR-mediated therapeutic editing of metabolic genes

Nature Network Boston, 2018
In utero gene editing has the potential to prenatally treat genetic diseases that result in significant morbidity and mortality before or shortly after birth.
A. Rossidis, John Stratigis, A. Chadwick, Heather A. Hartman, Nicholas J. Ahn, Haiying Li, Kshitiz Singh, Barbara E. Coons, Li Li, Wenjian Lv, P. Zoltick, D. Alapati, W. Zacharias, Rajan Jain, E. Morrisey, K. Musunuru, W. Peranteau   +16 more
semanticscholar   +1 more source