Results 181 to 190 of about 7,982,325 (356)
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
OBSERVATIONS ON THE PROTEOLYTIC ACTIVITY IN VITRO AT NEUTRAL REACTION OF GASTRIC JUICE FROM PATIENTS WITH SPRUE 1 [PDF]
, 1949 Herbert Fox
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FEBS Open Bio, EarlyView.GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda +15 more
wiley +1 more source
THE ACTION OF SULPHANILAMIDE ON RABBITS' LENSES IN VITRO [PDF]
, 1947 A. Bakker
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A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
Il metabolismo degli ormoni sessuali da parte degli Anfibi: Ricerche invitroein vivo [PDF]
, 1956 Giovanni Chieffi
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Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
CYANIDE LOSS FROM MEDIA IN STUDIES OF TISSUE METABOLISM IN VITRO
, 1945 Benjamin C. Riggs
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FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
The Growth of Plant Embryos in Vitro. Preliminary Experiments on the Rôle of Accessory Substances [PDF]
, 1937 James Bonner, Grice Axtman
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