Results 111 to 120 of about 272,120 (295)

Establishment of Eremanthus incanus in vitro

, 2019
Objetivou-se avaliar procedimentos para introdução in vitro de brotações retiradas de mudas de candeia mantidas em viveiro. Para a desinfestação das brotações, testou-se tempos de imersão (5, 10, 15 e 20 min) em hipoclorito de sódio a 2,5% e a influência do uso de fungicida antes (7 e 15 dias) e após a coleta das brotações, nas concentrações de 0,5 e 1,
Miranda, Natane Amaral, Titon, Miranda, Pereira, Israel Marinho, Fernandes, José Sebastião Cunha, Santos, Marcone Moreira   +4 more
openaire   +1 more source

In vitro sexual dimorphism establishment in schistosomes

Abstract Schistosomes are parasitic flatworms that cause Schistosomiasis, a major Neglected Tropical Disease (NTD) that affects more than 250 million people worldwide. With two morphologically distinct sexes, a heterogametic female (ZW) and a homogametic male (ZZ), schistosomes are an exception among flatworms, which ...
Magda E Lotkowska, Remi Pichon, Jude LD Bulathsinghalage, Madeleine McMath, Mary Evans, Benjamin J Hulme, Kirsty Ambridge, Geetha Sankaranarayanan, Simon Kershenbaum, Sarah D Davey, Josephine E Forde-Thomas, Karl F Hoffmann, Matthew Berriman, Gabriel Rinaldi   +13 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of an in vitro hairless guinea pig dermal model

PLoS ONE
Hairless guinea pigs (HGP) make a desirable model for percutaneous exposure because they do not need to be clipped and are lower in cost and less sentient than swine.
Samantha Emma Sarles, Priscilla Lee, Linnzi Wright, Daniel Angelini   +3 more
doaj   +2 more sources

Benefiting from the past: establishing in vitro culture of European beech (Fagus sylvatica L.) from provenance trial trees and seedlings

Plant Methods
Background European beech (Fagus sylvatica L.) is distributed across diverse climate conditions throughout Europe. Local adaptations, such as drought tolerance, could become crucial for maintaining beech populations facing climate change.
Virginia Zahn, Alexander Fendel, Alice-Jeannine Sievers, Matthias Fladung, Tobias Bruegmann   +4 more
doaj   +1 more source

Is It Possible to Produce Certified Hazelnut Plant Material in Sicily? Identification and Recovery of Nebrodi Genetic Resources, in vitro Establishment, and Innovative Sanitation Technique From Apple Mosaic Virus. [PDF]

Front Plant Sci, 2021
Yahyaoui E, Marinoni DT, Botta R, Ruffa P, Germanà MA.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

In vitro establishment of Phalaenopsis

Biotecnología Vegetal, 2007
The present work had as objectives to establish in vitro axillary buds of the floral stalk and to germinate in vitro botanical seeds of Phalaenopsis to obtain the formation of protocorm like bodies. As vegetable material axillary buds of the floral stalk
Manuel de Feria, Maité Chávez, Elisa Quiala   +2 more
doaj