Results 221 to 230 of about 272,120 (295)

Establishment of an <i>in vivo</i>-based assay using a silkworm infection model for phenotypic evaluation of antimicrobial drug combinations against <i>Mycobacterium abscessus</i>. [PDF]

Antimicrob Agents Chemother
Yagi A, Shinohara M, Minato Y, Uchida R.
europepmc   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Polyploidy and stress. [PDF]

Proc Natl Acad Sci U S A
Soltis DE, Fox DT, Soltis PS.
europepmc   +1 more source

Establishing an in vitro decidualization model in mice.

ADVANCES IN OBSTETRICS AND GYNECOLOGY, 1997
ISHIKAWA, Hironobu, TAKAKURA, Kenji, YAMADE, Ichiro, HAYASHI, Yoshihiko, GOTO, Sakae, HIROSE, Masaya, NODA, Yoichi   +6 more
openaire   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Gastric cancer organoids: a promising model for personalized treatment of gastric cancer. [PDF]

Front Cell Dev Biol
Chang Y, Liu Y, Zhang H, Lei X, Hu Y.
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Establishment of Patient-Derived Organoids for Pediatric Cancer Research. [PDF]

Cancers (Basel)
Younis M, Arjmandi T, Haque M, McClain K, Walter-Angelo T, Back F, Gandra D, Moore A, Behura C, Spiegelman VS, Wang HG, Dovat S, Hengst J, Sholler GS.   +13 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

A novel <i>in vitro</i> cyclic micropropagation protocol and assessment of genetic fidelity in the critically endangered woody species <i>Carpinus putoensis</i>. [PDF]

Front Plant Sci
Chen P, Zheng W, Xie Y, Chen Y, Ge B, Hu Y, Zhu M.   +6 more
europepmc   +1 more source