Results 251 to 260 of about 272,120 (295)

Establishment of in-vitro models of chemotherapy resistance

Anti-Cancer Drugs, 2007
Chemotherapy resistance is one of the most prevalent obstacles to the treatment of cancer, resulting in increased mortality and prolonged exposure to cytotoxic agents with no treatment benefit. One of the tools utilized in the study of mechanisms of chemotherapy resistance are established cell lines derived from human neoplasms. These cell lines can be
Mark B, Watson, Michael J, Lind, Lynn, Cawkwell   +2 more
openaire   +2 more sources

Establishment of a naphthalene cataract model in vitro

Experimental Eye Research, 1992
In the past, almost all studies on naphthalene cataract were based on in vivo experiments. Such studies are laborious and time-consuming and are complicated by systemic toxicity arising from the metabolites of naphthalene. In order to study the direct effects of naphthalene metabolites on the lens, we established an in vitro 'naphthalene cataract ...
G T, Xu, J S, Zigler, M F, Lou
openaire   +2 more sources

Brassavola tuberculata Hook.: in vitro growth and ex vitro establishment as a function of the micropropagation system and sucrose [PDF]

Brazilian Journal of Biology, 2023
This study examines the in vitro growth and ex vitro establishment of Brassavola tuberculata in relation to the micropropagation system and sucrose concentration employed in the in vitro culture.
Jackeline Schultz Soares, Lucas Coutinho Reis, Luan Marlon Ribeiro   +2 more
exaly   +3 more sources

Establishing Liver Bioreactors for In Vitro Research

2014
In vitro systems that can effectively model liver function for long periods of time are fundamental tools for preclinical research. Nevertheless, the adoption of in vitro research tools at the earliest stages of drug development has been hampered by the lack of culture systems that offer the robustness, scalability, and flexibility necessary to meet ...
Sofia P, Rebelo, Rita, Costa, Marcos F Q, Sousa, Catarina, Brito, Paula M, Alves   +4 more
openaire   +2 more sources

Establishing an In Vitro Fertilization Program

Hospital Practice, 1984
As in vitro fertilization becomes more acceptable, it will become a standard procedure in any obstetrics-gynecology service that seeks to offer a full range of tertiary care. Experience with development and operation of such a service is described in detail, as is the procedure itself—from oocyte extraction, fertilization, and transfer of the embryo to
openaire   +2 more sources

Establishment of an Embryo Implantation Model In Vitro

Journal of Visualized Experiments
Embryo implantation is the first step in the establishment of a successful pregnancy. An in vitro model for embryo implantation is critical for basic biological research, drug development, and screening. This paper presents a simple, rapid, and highly efficient in vitro model for embryo implantation.
Xuemei, Wang, Yisi, Sun, Huijuan, Shi, Aijie, Xin   +3 more
openaire   +2 more sources

The Establishment of an In Vitro Fertilization Programme

1984
Community interest following IVF has been stimulated by the extensive media coverage of pregnancies resulting from the use of this technique to treat human infertility. However, only a small number of fertility research teams have reported consistent success. This chapter reviews the requirements needed to establish an IVF and ET programme. Concern has
John Kerin, Carl Wood, Gabor Kovacs
openaire   +1 more source

The Establishment of Human Choriocarcinoma Cell Line in Vitro

Asia-Oceania Journal of Obstetrics and Gynaecology, 1983
AbstractA new tissue culture cell line, designated NUC‐1, has been established from human choriocarcinoma of the uterus. The cell line has now been growing in vitro for 28 months and has been subcultured 32 times. The cell grew in a monolayer sheet, showed a marked tendency to pile up, and released human chorionic gonadotropin (hCG) in media.
K, Suzumori, Y, Sugimoto, K, Suzjmori, Y, Yagami, A, Takeda   +4 more
openaire   +2 more sources

Perspectives of in vitro dissolution tests in establishing in vivo/in vitro correlations

European Journal of Drug Metabolism and Pharmacokinetics, 1993
Perspectives of in vitro dissolution tests in establishing an in vivo/in vitro correlation are considered at three different levels. The first involves the selection of a drug product, or suitable batch(es), for the correlation study. This requires evaluation of the biopharmaceutical properties of the proposed drug from a profile compiled from a set of
openaire   +2 more sources

Establishment of in vitro model of corneal scar pathophysiology

Journal of Cellular Physiology, 2017
Corneal scarring is the major source of permanent blindness worldwide. The complex pathophysiology of corneal scarring is not comprehensibly understood as it involves the interaction of a constellation of pro‐fibrotic cytokines influencing several signaling pathways involved in corneal scar development. In the present study, an attempt has been made to
Shikha Chawla, Sourabh Ghosh
openaire   +2 more sources