Results 71 to 80 of about 20,114 (319)

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Ruptured Tubal Triplet Heterotopic Pregnancy After in Vitro Fertilisation: A Case Report

Gynecology Obstetrics & Reproductive Medicine, 2011
To analyse the incidence, diagnostic and therapeutic management of heterotopic pregnancy following in vitro fertilisation (IVF). We present a case who had a ruptured left tubal heterotopic triplet pregnancy at nine weeks of gestation following in vitro ...
Mehmet Osmanağaoğlu, Murat Aksoy, Ceylan İlhan, Recep Erin   +3 more
doaj  

Manipulation of bicarbonate concentration in sperm capacitation media improves in vitro fertilisation output in porcine species

Journal of Animal Science and Biotechnology, 2019
Background The in vivo concentration of bicarbonate (HCO3 −), one of the essential sperm capacitating effectors, varies greatly in the different environments sperm go through from cauda epididymis to the fertilisation site.
Cristina Soriano-Úbeda, Jon Romero-Aguirregomezcorta, Carmen Matás, Pablo E. Visconti, Francisco A. García-Vázquez   +4 more
doaj   +1 more source

Effect of lifestyle or metformin interventions before IVF/ICSI treatment on infertile women with overweight/obese and insulin resistance: a factorial design randomised controlled pilot trial

Pilot and Feasibility Studies, 2023
Background For infertile women with overweight/obesity and insulin resistance (IR), it is uncertain whether intervention before infertility treatment can improve live birth rate (LBR).
Xiaojuan Wang, Sufen Cai, Sha Tang, Lanlin Yang, Jing Tan, Xin Sun, Fei Gong   +6 more
doaj   +1 more source

Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilisation (IVF) in couples with non-severe male infertility (NSMI-ICSI): protocol for a multicentre randomised controlled trial

BMJ Open, 2019
Introduction Intracytoplasmic sperm injection (ICSI), originally introduced as add-on to in vitro fertilisation (IVF) for couples with severe male infertility, is in current clinical practice also used in couples with mild male or even unexplained ...
D. Zheng, L. Zeng, R. Yang, Y. Lian, Yi-Min Zhu, Xiao-yan Liang, Li Tang, Huichun Wang, Yunxia Cao, G. Hao, Jianqiao Liu, Junli Zhao, Rui Wang, B. Mol, Rong Li, He-feng Huang, J. Qiao   +16 more
semanticscholar   +1 more source

Genetic Deconvolution of Embryonic and Maternal Cell‐Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning

Advanced Science, EarlyView.
DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou   +3 more
wiley   +1 more source

Transcutaneous electrical acupuncture point stimulation improves pregnancy outcomes in patients with recurrent implantation failure undergoing in vitro fertilisation and embryo transfer: a prospective, randomised trial

Acupuncture in Medicine, 2019
Objective: To evaluate the effect of transcutaneous electrical acupuncture stimulation (TEAS) on pregnancy outcomes in patients with recurrent implantation failure (RIF) undergoing in vitro fertilisation (IVF).
Zhenhong Shuai, Xuemei Li, Xuelian Tang, F. Lian, Zhengao Sun   +4 more
semanticscholar   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis.

Cochrane Database of Systematic Reviews, 2019
BACKGROUND Endometriosis is known to have an impact on fertility and it is common for women affected by endometriosis to require fertility treatments, including in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI), to improve the ...
Ektoras X Georgiou, Pedro Melo, Philip E Baker, Hassan N. Sallam, Aydin Arici, J. García-Velasco, A. Abou-Setta, C. Becker, I. Granne   +8 more
semanticscholar   +1 more source