Results 41 to 50 of about 114,132,657 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sexual Function and in Vitro Fertilization

Acta clinica Croatica, 2022
Cilj istraživanja bio je ispitati seksualnost osoba koje liječe neplodnost postupcima izvantjelesne oplodnje. Naglasak istraživanja bio je na seksualnoj disfunkciji, seksualnom zadovoljstvu i povezanim čimbenicima rizika. Podaci su prikupljeni na osnovi validiranog i standardiziranog upitnika. Uzorak je činilo 119 ispitanika koji su liječeni postupcima
Andrej Starc, Sanela Aljija, Tomislav Jukić, Raja Dahmane Gošnak, Ante Rotim, Doroteja Pavan Jukić   +5 more
openaire   +4 more sources

Determination of non-invasive viability markers for human embryos in in vitro fertilization. [PDF]

, 2010
The major challenge currently facing human in vitro fertilization (IVF) programs is the prevention of multiple gestation pregnancies. The replacement of multiple embryos to fertility patients is common practice to increase pregnancy rates.
Feil, Deanne Kate
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

A Strategic Program for Risk Assessment and Intervention to Mitigate Environmental Stressor-Related Adverse Pregnancy Outcomes in the Indian Population

Frontiers in Reproductive Health, 2021
The Problem: Global environmental stressors of human health include, but are not limited to, conflict, migration, war, natural disasters, climate change, pollution, trauma, and pandemics.
Divyanu Jain, Ajay K. Jain, Ajay K. Jain, Gerlinde A. S. Metz, Nina Ballanyi, Abha Sood, Rupert Linder, David M. Olson, David M. Olson   +8 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Luteinizing hormone dynamics during progestin-primed ovarian stimulation do not predict follicular output in women with normo-ovarian reserve

Frontiers in Endocrinology
BackgroundProgestin-primed ovarian stimulation (PPOS) has emerged as an effective alternative to conventional pituitary suppression strategies in assisted reproductive technology cycles.
Fazilet Kubra Boynukalin, Meral Gultomruk, Neslihan Sonmez, Peter Humaidan, Mustafa Bahceci, Gurkan Bozdag   +5 more
doaj   +1 more source

How a woman’s myomectomy saved her father’s life: evidence of fumarate hydratase–deficient uterine leiomyoma and early detection of germline variants in fumarate hydratase

F&S Reports, 2022
Objective: To describe a case of a personal and family history of early uterine leiomyomatosis that revealed a pathogenic variant in the FH gene encoding fumarate hydratase.
Greysha Rivera-Cruz, M.D., Baris Boyraz, M.D., Ph.D., John C. Petrozza, M.D.   +2 more
doaj   +1 more source

Establishment of contaminant-free perennial plants in vitro

, 1999
Perennial plant tissue cultures are established by disinfecting field or greenhouse-grown plant parts and transferring them to sterile medium in vitro. Typically, shoots harvested from field or greenhouse-grown plants are placed in water, either to force
McMeans O.M., Özgür, M., Motoike S., Norton M.A., Skirvin R.M., Al-Juboory K.   +5 more
core   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source