Results 141 to 150 of about 28,412 (311)

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Effect of Medium Composition and Culture Conditions on the In Vitro Multiplication, Rooting and Acclimatization of Helleborus ‘Molly’s White’ and ‘Anna’s Red’

Journal of Horticultural Research
The genus Helleborus belongs to the family Ranunculaceae and comprises about 22 species, which are distributed across Europe and West Asia. Hellebores are popular as garden perennials, pot plants, cut flowers, and medicinal plants.
Gabryszewska Eleonora Anna, Norwa Krystyna, Norwa Piotr, Majos Dorota   +3 more
doaj   +1 more source

Phylogenetic patterns recover known HIV epidemiological relationships and reveal common transmission of multiple variants. [PDF]

, 2018
The growth of human immunodeficiency virus (HIV) sequence databases resulting from drug resistance testing has motivated efforts using phylogenetic methods to assess how HIV spreads1-4.
Leitner, Thomas, Romero-Severson, Ethan
core   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Improved in vitro rooting in liquid culture using a two piece scaffold system. [PDF]

Eng Life Sci, 2020
Shukla MR, Piunno K, Saxena PK, Jones AMP.   +3 more
europepmc   +1 more source

Chromosome instability in 'Carrizo' citrange + Citrus macrophylla somatic hybrids [PDF]

, 2015
Somatic hybridization by protoplast fusion is a very useful technique for citrus rootstock breeding. Indeed, it theoretically allows the accumulation of all genes of the parents, irrespective of their heterozygosity level and therefore the addition of ...
Aleza, Pablo, Navarro, Luis, Olivares-Fuster, Oscar, Ollitrault, Patrick, Pensabene-Bellavia, Giovani, Ruiz, Marta   +5 more
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Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Influence of plant regulators on the micropropagation of Echinacea purpurea ‘Raspberry Truffle’

Acta Scientiarum Polonorum: Hortorum Cultus
A micropropagation protocol was conducted for Echinacea purpurea ‘Raspberry Truffle’ to determine the influence of medium amendment with a plant growth regulator (PGR).
Nabilah A. Samsurizal, Karolina Nowakowska, Andrzej Pacholczak   +2 more
doaj   +1 more source

In vitro propagation of insectivorous plants for phytochemical purposes [PDF]

, 2009
Dissertação mest., Engenharia Biológica, Universidade do Algarve, 2009The aims of this research work were to establish in vitro propagation protocols for the insectivorous plants D. intermedia, D. rotundifolia and P.
Coelho, Natacha
core