Results 91 to 100 of about 2,915,776 (318)

Round robin study to evaluate the reconstructed human epidermis (RhE) model as an in vitro skin irritation test for detection of irritant activity in medical device extracts.

, 2018
Assessment of skin irritation is an essential component of the safety evaluation of medical devices. OECD Test Guideline 439 describes the use of reconstructed human epidermis (RhE) as an in vitro test system for classification of skin irritation by neat
Timothy Schatz, Lee, Michelle, Rollins, Beau,, Skoog, Shelby,, Briotet, Damien,, De La Fonteyne, Liset, Helena Kandárová, Tornier, Carine, Schatz, Timothy,, Rollins, Beau, Sawyer, Anita, Christiano, Nicholas,, Marisa Meloni, Gehrke, Helge,, Reiko Kato, Michelle Lee, Paolo Pescio, Meloni, Morisa,, Kandárová, Helena, Christiano, Nicholas, Sebastian Hoffmann, Videau, Christelle, Letasiova, Silvia,, Hofman-Hüther, Hana, Kato, Reiko,, Gehrke, Helge, Hoffmann, Sebastian, Austin Zdawczyk, Kim, Kwang-Mahn,, Kwon, Jae Sung, Hana Hofman-Hüther, Willoughby, Jamin,, Sawyer, Anita,, Letasiova, Sylvia, Christian Pellevoisin, Haishima, Yuji,, Carine Tornier, Julius, Conrad,, Nicholas Christiano, Shelby Skoog, Coleman, Kelly P, Haishima, Yuji, Jamin Willoughby, Briotet, Damien, Damien Briotet, Hofman-Hüther, Hana,, Helge Gehrke, Zdawzcyk, Austin, Parker, Sherry, Bachelor, Michael, Beau Rollins, Rollins, Thor S.,, De Jong, Wim H, Miyajima, Atsuko, Schatz, Timothy, Pescio, Paolo, Julius, Conrad, Videau, Christelle,, Tornier, Carine,, Turley, Audrey P.,, Kato, Reiko, Turley, Audrey, Kelly P. Coleman, Atsuko Miyajima, Pellevoisin, Christian, Fant, Kristina,, Pellevoisin, Christian,, Wim H. De Jong, Anita Sawyer, Bachelor, Michael,, Miyajima, Atsuko,, Christelle Videau, Zdawczyk, Austin,, Meloni, Marisa, Parker, Sherry,, Kwon, Jae Sung,, Kristina Fant, Jae Sung Kwon, Coleman, Kelly P.,, Lee, Michelle,, Thor S. Rollins, Yuji Haishima, Audrey P. Turley, Fant, Kristina, Conrad Julius, Willoughby, Jamin, Silvia Letasiova, Michael Bachelor, Sherry Parker, De La Fonteyne, Liset J. J.,, Pescio, Paolo,, Kim, Kwang-Mahn, Liset J.J. De La Fonteyne, Rollins, Thor, Hoffmann, Sebastian,, De Jong, Wim H.,, Kandárová, Helena,, Skoog, Shelby, Kwang-Mahn Kim   +98 more
core   +2 more sources

Comparative Profilometric Evaluation of Chewable Toothpaste Tablets and Conventional Toothpaste: An In vitro Study

Journal of Indian Association of Public Health Dentistry
Aim: The present study was undertaken to evaluate and compare the surface roughness and pH of chewable toothpaste tablet with conventional toothpaste. Materials and Methods: Twenty freshly extracted teeth specimens (10/group) were brushed using chewable ...
Snehal Sakharam Patil, V. K. Prashanth, Arun S. Dodamani, Harish Chaitram Jadhav, Swapnali Patil, Snehal Thamke   +5 more
doaj   +1 more source

In vitro study of RRS HA injectable mesotherapy/biorevitalization product on human skin fibroblasts and its clinical utilization

, 2016
Pierre-Antoine Deglesne,* Rodrigo Arroyo,* Evgeniya Ranneva, Philippe Deprez Research and Development, SKIN TECH PHARMA GROUP, Castelló d'Empúries, Spain  *These authors contributed equally to this work Abstract: Mesotherapy ...
Ranneva E, Deprez P, Arroyo R, Deglesne PA   +3 more
core  

Hepatic intracellular free drug concentration and unbound partition coefficient: development and validation of an in vitro methodology to predict in vivo liver drug exposure

, 2023
reservedThe Free drug hypothesis states that only the unbound drug molecules are able, in the site of action, to interact with the target and exert the pharmacodynamic effect.
FONTANA, NICCOLÒ
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs

Scientific Reports
Squalene epoxidase (SQLE) is a crucial enzyme in the cholesterol-biosynthesis pathway and a promising target for treating cholesterol-related disorders.
Emadeldin M. Kamel, Noha A. Ahmed, Faris F. Aba Alkhayl, May Bin-Jumah, Naif G. Altoom, Fahad M. Alshabrmi, Saleh Maodaa, Al Mokhtar Lamsabhi   +7 more
doaj   +1 more source

Validation of in vitro methods for human cytochrome P450 enzyme induction : Outcome of a multi-laboratory study [PDF]

, 2019
CYP enzyme induction is a sensitive biomarker for phenotypic metabolic competence of in vitro test systems; it is a key event associated with thyroid disruption, and a biomarker for toxicologically relevant nuclear receptor-mediated pathways.
Chesne, Christophe, Liska, Roman, Strickland, Judy, Pelkonen, Olavi, Wilk-Zasadna, Iwona, Müller-Vieira, Ursula, Bernasconi, Camilla, Worth, Andrew, Andersson, Tommy B., Coecke, Sandra, Richert, Lysiane, Asturiol, David, Cole, Thomas   +12 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes

International Journal of Nanomedicine, 2010
Preety Panwar1, Bhumika Pandey1, P C Lakhera2, K P Singh11Biophysics and Nanotechnology Research Laboratory, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India; 2Department of Biotechnology, H.N.B. Garhwal University,
Preety Panwar, Bhumika Pandey, P C Lakhera, et al   +3 more
doaj  

Infection and disinfection of transmucosal implant surfaces "in vitro" [PDF]

, 2013
Peri-implantitis is an inflammatory process, which is initiated by a biofilm-induced pathway causing a reversible inflammatory reaction in the soft tissues surrounding the implant; however, it may progress into irreversible damage in the surrounding ...
Astašov-Frauenhoffer, Monika
core   +1 more source