Results 131 to 140 of about 118,707,215 (312)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
La manifattura in provincia di Napoli
, 2014 La manifattura industriale ha storicamente contrassegnato le vicissitudini socio-economiche della provincia di Napoli, con delle significative ripercussioni anche sulla regione e sullo stesso Mezzogiorno.
DE VIVO, PAOLA, PISCITELLI, ALFONSO
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Ohio Retirement Study Council comparative performance study, period ending Dec. 31, 2002
, 2002 Semiannual; Nov. 13, 2000-; Title from cover of PDF document (viewed Feb. 13, 2006).; Vol. for 2002-2003 prepared by Milliman USA; vol. for 2004- prepared by Evaluation Associates.; Some vol. also called quarters.; Chronological designation based on date
Ohio Retirement Study Council
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Il ruolo delle politiche industriali in Campania.
, 2018 Il capitolo offre un'analisi in merito agli esiti e alle prospettive delle politiche industriali, ideate sia in ambito nazionale che europeo, implementate in ...
Paola De Vivo
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
, 2014 [[abstract]]Numerous studies have shown that phenethyl isothiocyanate (PEITC) induces apoptosis of different types of human cancer cell lines, however, there are no reports showing that PEITC inhibits tumor growth in a xenograft model of melanoma in nude
WEI-YA, NI;WEI-YA, NI;HSU-FENG, LU;HSU-FENG, LU;HSU, SHU-CHUN;HSU, SHU-CHUN;HSIA, YU-PING;HSIAO, YU-PING;KUO-CHING, LI;LIU, KUO-CHING;LIU, JIA-YOU;LIU, JIA-YOU;BIN-CHUAN, JI;BIN-CHUAN, JI;SHU-CHING, HS;HSUEH, SHU-CHING;鍾景光*
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